Relationship Between Low Back Pain and Sensitization

NCT ID: NCT06958263

Last Updated: 2025-05-11

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 72 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-05-08
• Study Completion Date: 2026-03-01

Brief Summary

Chronic non-specific low back pain is a common health problem that significantly affects the quality of life of individuals. Increased pain intensity leads to deficiencies in the body's sensory organization, resulting in decreased awareness. This can lead to dysfunction in body awareness, which is known as the ability of individuals to perceive the sensations and conditions of their bodies. Body awareness plays a critical role in pain management and mobility. Chronic pain causes constant stimulation in the nervous system, causing central sensitization, which is when the central nervous system becomes overly sensitive to pain signals. As a result, a decrease in the pain threshold, constant pain, and increased muscle tension occur. Increased pain intensity and decreased awareness can result in a decrease in the maintenance of optimal functions, affecting muscular endurance. Inadequate muscular endurance can increase low back pain and make it difficult for individuals to perform their daily activities. Therefore, this study aims to examine the relationship between body awareness, central sensitization, disability, and muscular endurance in patients with chronic non-specific low back pain.

Detailed Description

Body awareness plays a critical role in pain management and mobility. Individuals with high body awareness can better manage their pain, which can contribute to a decrease in disability levels. Chronic pain causes constant stimulation in the nervous system, which causes central sensitization, which is when the central nervous system becomes oversensitive to pain signals. As a result, a decrease in the pain threshold, constant pain, and increased muscle tension occur. In addition, central sensitization can cause the body to be more vulnerable to injuries due to the body being in an overstimulated state. Increased pain intensity and decreased awareness can result in a decrease in the maintenance of optimal functions, affecting muscular endurance. Inadequate muscular endurance can increase low back pain and make it difficult for individuals to perform their daily activities. The literature has attempted to emphasize the relationship between pain, disability, and body awareness in various populations. However, the relationship between body awareness and central sensitization has not been sufficiently studied. Sensitization in the body as a result of central sensitization may be associated with changes in awareness. Understanding these complex relationships is important for developing appropriate treatment strategies in the rehabilitation and clinical follow-up process. Therefore, this study aims to investigate the relationship between body awareness, central sensitization, disability and muscular endurance in patients with chronic non-specific low back pain. Patients with chronic non-specific low back pain will be included in the study. Body awareness, central sensitization, pain intensity, muscular endurance and disability levels of the patients will be evaluated. The data obtained from the study will be analyzed appropriately.

Conditions

Low Back Pain

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Higher sensitization

Patients with chronic non-specific low back pain with high sensitization will be included.

No interventions assigned to this group

Normal sensitization

Patients with chronic non-specific low back pain with normal sensitization will be included.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Being between the ages of 18-65
• Being diagnosed with chronic non-specific low back pain (Pain between the gluteal folds and the 12th ribs that lasts at least 12 weeks and has no known pathoanatomical cause)
• Being willing to participate in the study

Exclusion Criteria

• Having a psychological disorder, mental disorder, cancer and severe depression
• Having a history of primary or metastatic spinal malignancy, spinal fracture
• Having a neurological disease (Hemiplegia, Multiple Sclerosis, Parkinson's, etc.)
• Being diagnosed with advanced osteoporosis
• Having a history of surgery or acute infection in the lumbar region

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Karabuk University

OTHER

Sponsor Role: lead

Responsible Party

Musa Güneş

Principal Investigator, PhD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Musa Güneş, PhD

Role: STUDY_DIRECTOR

Karabuk University

Seher İmanur

Role: PRINCIPAL_INVESTIGATOR

Karabuk University

Elif Aydoğan

Role: PRINCIPAL_INVESTIGATOR

Karabuk University

Bedirhan Turan

Role: PRINCIPAL_INVESTIGATOR

Karabuk University

Aydın Sinan Apaydın, PhD

Role: PRINCIPAL_INVESTIGATOR

Karabuk University

Locations

Karabuk University, Physiotherapy and Rehabilitation Application and Research Center

Karabük, , Turkey (Türkiye)

Site Status: RECRUITING

Countries

Turkey (Türkiye)

Central Contacts

Musa Güneş, PhD

Role: CONTACT

musagunes52@hotmail.com

05315132482

Facility Contacts

Musa Güneş, MsC

Role: primary

musagunes@karabuk.edu.tr

+905315132482

References

Nijs J, Van Houdenhove B, Oostendorp RA. Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice. Man Ther. 2010 Apr;15(2):135-41. doi: 10.1016/j.math.2009.12.001. Epub 2009 Dec 24.

Reference Type: BACKGROUND

PMID: 20036180 (View on PubMed)

Colgan DD, Eddy A, Green K, Oken B. Adaptive body awareness predicts fewer central sensitization-related symptoms and explains relationship between central sensitization-related symptoms and pain intensity: A cross-sectional study among individuals with chronic pain. Pain Pract. 2022 Feb;22(2):222-232. doi: 10.1111/papr.13083. Epub 2021 Nov 11.

Reference Type: RESULT

PMID: 34651401 (View on PubMed)

Other Identifiers

Karabuk-003

Identifier Type: -

Identifier Source: org_study_id