Physiotherapy and Reaction Time in Hemophilia

NCT ID: NCT06331091

Last Updated: 2024-04-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-10

Study Completion Date

2024-01-19

Brief Summary

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This randomised controlled study was conducted to investigate the comprehensive physiotherapy combined with home exercises on individuals with hemophilic arthropathy in the lower extremity. There are two groups in the study: home exercises and comprehensive physiotherapy combined with home exercises. Is physiotherapy combined with home exercises superior to home exercises on joint health, bleeding frequency, reaction time, dynamic balance, muscle strength? The aim of this study is to increase the compliance of hemophilic individuals to physiotherapy and adapt home exercises to their lives with weekly sessions.

Detailed Description

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Introduction: The positive effects of physiotherapy and exercise on joint health, frequency of hemartrosis (FoH) in patient with hemophilic arhropathy (PwHA) are well explained in the literature. However, adaptation problems to physiotherapy sessions (usually 3 times a week) may cause PwHA to ignore the need for therapy. It may be more beneficial for PwHA to adapt physiotherapy and exercise into daily live.

Aim: To investigate the effect of a once-a-week physiotherapy combined with home exercises on joint health, FoH, muscle strength, pain, reaction time and dynamic balance.

Methods: 20 patients have hemophilic arthropathy in knee and/or ankle were randomly divided into 2 groups, named home exercise (HE) and comprehensive physiotherapy combined with home exercise (CPcwHE). In the clinical assessment, HJHS, manuel muscle tester, Fitlight® system for reaction time, functional reach test for dynamic balance were used and questioned the number of bleedings in the last 6 weeks for FoH. The CP group received comprehensive physiotherapy (manual therapy, neuromuscular electrical stimulation and exercises) 1 day a week, and did the exercises at home the other 2 days a week. The HE group performed the exercises given to CP at home 3 times a week. Evaluations were repeated at the end of 6 weeks.

Conditions

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Hemophilia Arthropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomised controlled study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Home exercise

This group performed the same exercises given to comprehensive physiotherapy group at home 3 times a week for 6 weeks.

Group Type ACTIVE_COMPARATOR

Home exercise

Intervention Type OTHER

Home exercise are done at home without the supervision of a specialist.

Comprehensive physiotherapy

This group received comprehensive physiotherapy (manual therapy, neuromuscular electrical stimulation and exercises) 1 day a week, and did the exercises at home the other 2 days a week for 6 weeks.

Group Type EXPERIMENTAL

Home exercise

Intervention Type OTHER

Home exercise are done at home without the supervision of a specialist.

Manual therapy

Intervention Type OTHER

Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist.

Neuromuscular electrical stimulation

Intervention Type DEVICE

Home exercise are done at home without the supervision of a specialist. Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist.

Neuromuscular electrical stimulation is the application of electrical current to the muscle through special electrodes in order to increase muscle strength.

Supervised exercise is done under the supervision of a physiotherapist.

Supervised exercise

Intervention Type OTHER

Supervised exercise is done under the supervision of a physiotherapist.

Interventions

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Home exercise

Home exercise are done at home without the supervision of a specialist.

Intervention Type OTHER

Manual therapy

Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist.

Intervention Type OTHER

Neuromuscular electrical stimulation

Home exercise are done at home without the supervision of a specialist. Manual therapy is special techniques for soft tissues and joints applied by a physiotherapist.

Neuromuscular electrical stimulation is the application of electrical current to the muscle through special electrodes in order to increase muscle strength.

Supervised exercise is done under the supervision of a physiotherapist.

Intervention Type DEVICE

Supervised exercise

Supervised exercise is done under the supervision of a physiotherapist.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

-Clinical diagnosis of hemophilic arthropathy in ankle and/or

Exclusion Criteria

* Clinical diagnosis of any neurological disease
Minimum Eligible Age

10 Years

Maximum Eligible Age

32 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Yuzuncu Yıl University

OTHER

Sponsor Role lead

Responsible Party

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Ayse Merve TAT

Assisstant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ayse Merve Tat, Asst. Prof.

Role: STUDY_CHAIR

Van Yüzüncü Yıl University, Faculty of Health Science

Necati Muhammed Tat

Role: PRINCIPAL_INVESTIGATOR

Van Yüzüncü Yıl University, Faculty of Health Science

Serbay Şekeröz, Asst. Prof.

Role: PRINCIPAL_INVESTIGATOR

Van Yüzüncü Yıl University, Faculty of Health Science

Meryem M Büke, Asst. Prof.

Role: PRINCIPAL_INVESTIGATOR

Van Yüzüncü Yıl University, Faculty of Health Science

Kamuran M Karaman, Prof.

Role: STUDY_CHAIR

Van Yüzüncü Yıl University, Faculty of Medicine

Locations

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Van Yüzüncü Yıl University

Van, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Tat AM, Tat NM, Sekeroz S, Buke M, Karaman K. Low frequency physiotherapy on joint health, hemarthrosis, walking, balance and reaction time in hemophilic arthropathy: a controlled trial. BMC Musculoskelet Disord. 2025 Apr 4;26(1):332. doi: 10.1186/s12891-025-08549-4.

Reference Type DERIVED
PMID: 40186132 (View on PubMed)

Other Identifiers

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YuzuncuYıl2022/2

Identifier Type: -

Identifier Source: org_study_id

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