The Effectiveness and Outcomes of Epidural Analgesia in Patients Undergoing Open Hepatectomy

NCT ID: NCT06301932

Last Updated: 2024-03-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 654 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-01-01
• Study Completion Date: 2023-12-31

Brief Summary

This observational study is to compare the effectiveness and outcomes of epidural analgesia in patients undergoing open hepatectomy: A propensity score matching analysis.

The main question is: What is the superior method of pain control in open hepatectomy: epidural analgesia or intravenous PCA?

Detailed Description

After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2562-06771), the investigators performed a retrospective review of all patients who underwent an elective open liver resection in the specialized hepato-biliary center from January 2007 through December 2018. This retrospective inquiry comprised 612 patients. The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected. The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, intra-operative opioid consumption and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. Post-operative pain score and opioid consumption also be collected.

Conditions

Epidural Analgesia; Patient Controlled Analgesia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

Epidural analgesia

Group of the patients received epidural analgesia

Open liver resection

Intervention Type: PROCEDURE

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Non epidural analgesia

Group of the patients who did not received epidural analgesia

Open liver resection

Intervention Type: PROCEDURE

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Interventions

Open liver resection

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• All gender age above 18 years old
• Undergoing open liver resection surgery

Exclusion Criteria

• No documentation of the numerical rating scale (NRS)
• Epidural failure

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Chiang Mai University

OTHER

Sponsor Role: lead

Responsible Party

Isarapong Pianngarn

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

References

Pianngarn I, Lapisatepun W, Kulpanun M, Chotirosniramit A, Junrungsee S, Lapisatepun W. The effectiveness and outcomes of epidural analgesia in patients undergoing open liver resection: a propensity score matching analysis. BMC Anesthesiol. 2024 Sep 2;24(1):305. doi: 10.1186/s12871-024-02697-1.

Reference Type: DERIVED

PMID: 39223470 (View on PubMed)

Other Identifiers

ANE-2562-06771

Identifier Type: -

Identifier Source: org_study_id