Complications of High Frequency Jet Ventilation

NCT ID: NCT06285994

Last Updated: 2025-05-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1385 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-03-03
• Study Completion Date: 2025-02-01

Brief Summary

High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:

• Hypoxia: SpO2 < 90% for 1 min
• Severe hypoxia: SpO2 < 85% for 1 min
• Hemodynamic instability, defined as Arterial pressure < 90/60
• Cardiac arrhythmia
• Laryngospasm or bronchospasm
• Barotrauma or volutrauma
• Need for ICU admission

A model predicting the risk for developing any complication will be developped using 2 mathematical methods:

• a multivariate analysis
• a data mining approach

For both approaches, the following variables will be included in the model:

• Age
• Gender
• Weight
• Height
• BMI
• Smoking
• Alcohol consumption
• Consumption of Other drugs
• ASA class
• Obstructive pulmonary disease
• Restrictive lung disease
• COPD status (1, 2, 3, 4)
• Interstitial lung disease
• Lung tumor

• Trachea location
• Carina location
• Bronchial location
• Pulmonary or tracheal stenosis
• Presence of stridor
• Severe stenosis (< 6 mm)
• Baseline SpO2 (pre-intervention)
• Pre-intervention oxygen requirement Procedure
• Duration (min)
• Stent placement
• Dilation
• Laser treatment
• Length of hospital stay Lung function tests
• FEV1 (forced expiratory volume)
• VC (Vital Capacity)
• FEV1/VC (Tiffeneau ratio)
• CPT (total lung capacity)
• DLCO (carbon monoxide diffusion)

Conditions

High-Frequency Jet Ventilation; Bronchoscopy

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

HFJV

All patients who underwent bronchoscopy with the use of high frequency jet ventilation between January 1st 2019 and december 31st 2023.

High frequency jet ventilation

Intervention Type: PROCEDURE

Use of high frequency jet ventilation during bronchoscopy

Interventions

High frequency jet ventilation

Use of high frequency jet ventilation during bronchoscopy

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels

Exclusion Criteria

• Incomplete medical chart
• Patient who expressed their opposition to the use of their medical data

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Erasme University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Hôpital Universitaire de Bruxelles - Hôpital erasme

Brussels, , Belgium

Countries

Belgium

References

Aravena C, Mehta AC, Almeida FA, Lamb C, Maldonado F, Gildea TR. Innovation in rigid bronchoscopy-past, present, and future. J Thorac Dis. 2023 May 30;15(5):2836-2847. doi: 10.21037/jtd-22-779. Epub 2023 Apr 25.

Reference Type: BACKGROUND

PMID: 37324083 (View on PubMed)

Putz L, Mayne A, Dincq AS. Jet Ventilation during Rigid Bronchoscopy in Adults: A Focused Review. Biomed Res Int. 2016;2016:4234861. doi: 10.1155/2016/4234861. Epub 2016 Oct 26.

Reference Type: BACKGROUND

PMID: 27847813 (View on PubMed)

Poling HE, Wolfson B, Siker ES. A technique of ventilation during laryngoscopy and bronchoscopy. Br J Anaesth. 1975 Mar;47(3):382-4. doi: 10.1093/bja/47.3.382.

Reference Type: BACKGROUND

PMID: 1138745 (View on PubMed)

Klain M, Smith RB. High frequency percutaneous transtracheal jet ventilation. Crit Care Med. 1977 Nov-Dec;5(6):280-7. doi: 10.1097/00003246-197711000-00007. No abstract available.

Reference Type: BACKGROUND

PMID: 338247 (View on PubMed)

Hautmann H, Gamarra F, Henke M, Diehm S, Huber RM. High frequency jet ventilation in interventional fiberoptic bronchoscopy. Anesth Analg. 2000 Jun;90(6):1436-40. doi: 10.1097/00000539-200006000-00034.

Reference Type: BACKGROUND

PMID: 10825336 (View on PubMed)

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Reference Type: BACKGROUND

PMID: 25741903 (View on PubMed)

Goudra BG, Singh PM, Borle A, Farid N, Harris K. Anesthesia for Advanced Bronchoscopic Procedures: State-of-the-Art Review. Lung. 2015 Aug;193(4):453-65. doi: 10.1007/s00408-015-9733-7. Epub 2015 Apr 29.

Reference Type: BACKGROUND

PMID: 25921014 (View on PubMed)

Fernandez-Bustamante A, Ibanez V, Alfaro JJ, de Miguel E, German MJ, Mayo A, Jimeno A, Perez-Cerda F, Escribano PM. High-frequency jet ventilation in interventional bronchoscopy: factors with predictive value on high-frequency jet ventilation complications. J Clin Anesth. 2006 Aug;18(5):349-56. doi: 10.1016/j.jclinane.2005.12.011.

Reference Type: BACKGROUND

PMID: 16905080 (View on PubMed)

Other Identifiers

SRB2024016

Identifier Type: -

Identifier Source: org_study_id