Protein Molecular Characteristics and Prognosis of Cervical Neuroendocrine Tumors

NCT ID: NCT06276309

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-01

Study Completion Date

2025-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were collected, including age, preoperative biopsy pathology results, postoperative histopathological results, TCT results, and colposcopy biopsy pathology results. At the same time, paraffin tissue specimens (remaining specimens after pathological diagnosis) from 100 cases of cervical neuroendocrine tumors from multiple centers across the country were collected to establish a cervical neuroendocrine tumor data follow-up database. Protein concentration and omics analysis were performed on the data results, to evaluate the molecular characteristics and prognosis of cervical neuroendocrine tumor proteins, and to preliminarily explore its clinical application value.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

1\. The clinical diagnosis and treatment data of 300 cases of cervical neuroendocrine tumors were used for prognostic analysis.

(1) The diagnosis and treatment information of cervical neuroendocrine carcinoma in multiple hospitals was collected, including clinical and medical data such as age, preoperative HPV genotyping, preoperative biopsy pathological results, postoperative histopathological results, FIGO staging, prognosis and survival information, and follow-up of patients.

2\. Protein and other omics analysis was performed on paraffin tissues of 100 cases of cervical neuroendocrine tumors Paraffin samples collected from 100 cases of cervical neuroendocrine tumors were identified, processed and segmtioned, and protein concentration and proteome were determined to establish the molecular characteristics and prognostic targets of cervical neuroendocrine tumors.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neuroendocrine Neoplasm China Women Cervical Cancer Cervical Lesion

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients diagnosed with cervical neuroendocrine carcinoma by histopathology
2. Clinical data were complete

Exclusion Criteria

1. Patients who are not being treated in our hospital
2. Patients with lack of follow-up data, unable to obtain survival information
3. Patients call to refuse to participate in this project
4. The quality of paraffin specimens can not meet the requirements of proteome concentration determination
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Fujian Maternity and Child Health Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Pengming Sun, PhD

Role: STUDY_CHAIR

Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Fujian Maternity and Child Health Hospital

Fuzhou, Fujian, China

Site Status RECRUITING

Fujian Provincial Hospital

Fuzhou, Fujian, China

Site Status RECRUITING

Ningde Mindong Hospital

Ningde, Fujian, China

Site Status RECRUITING

Putian City first Hospital

Putian, Fujian, China

Site Status RECRUITING

The Second Affiliated Hospital of Fujian Medical University

Quanzhou, Fujian, China

Site Status RECRUITING

Zhangzhou affiliated Hospital of Fujian Medical University

Zhangzhou, Fujian, China

Site Status RECRUITING

Maternal and Child Health Hospital of Hubei Province

Wuhan, Hubei, China

Site Status RECRUITING

Xiangya Hospital, Central South University

Changsha, Hunan, China

Site Status RECRUITING

Jiangxi maternal and Child Health Hospital

Nanchang, Jiangxi, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Binhua Dong

Role: CONTACT

+86-0591-87558732

Pengming Sun

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Binhua Dong

Role: primary

+8687558732

Dongjie Chen

Role: primary

Fang Xie

Role: primary

Yi Chen

Role: primary

Luhong Li

Role: primary

Feifeng Shi, M.D

Role: primary

Hongning Cai, M.D

Role: primary

+8615926224867

Yu Zhang

Role: primary

Ling Li

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

NECC2401

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.