A Chinese Cohort of Cervical Large Cell Neuroendocrine Carcinoma
NCT ID: NCT07240753
Last Updated: 2025-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
200 participants
OBSERVATIONAL
2025-12-01
2028-11-01
Brief Summary
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Detailed Description
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* Patient demographics (age, place of origin, occupation, etc.)
* Medical history and test results prior to initial treatment:
* Present illness history
* Tumor marker levels
* Pelvic ultrasound
* Whole abdomen CT/MRI
* PET-CT
* Surgical treatment details (date of surgery, surgical approach)
* Pathological examination results
* Administration of neoadjuvant chemotherapy and/or radiotherapy
* Detailed records of all treatment courses and their efficacy (including chemotherapeutic agents, radiotherapy doses, number of cycles, etc.)
* Results from follow-up examinations and imaging studies
* Recurrence status and, if applicable, time to recurrence
* Survival status and, if applicable, date of death For the retrospective cohort, follow-up will be completed within one month after enrollment to document current survival status and recurrence. For the prospective cohort, annual follow-ups will be conducted to record current survival status and recurrence.
Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Cervical Large Cell Neuroendocrine Carcinoma Cohort
Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Interventions
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Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Postoperative pathological examination confirmed cervical large cell neuroendocrine carcinoma.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
FEMALE
No
Sponsors
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
OTHER
Cancer Research Institute of Zhongshan City
OTHER_GOV
The First Affiliated Hospital of Zhengzhou University
OTHER
Qilu Hospital of Shandong University
OTHER
Fujian Province Tumor Hospital
OTHER
Fujian Maternity and Child Health Hospital
OTHER
Zhejiang Cancer Hospital
OTHER
The Third Affiliated Hospital of Kunming Medical College.
OTHER
Obstetrics & Gynecology Hospital of Fudan University
OTHER
Women's Hospital School Of Medicine Zhejiang University
OTHER
National Cancer Center/National Cancer Clinical Medical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
UNKNOWN
Peking Union Medical College Hospital
OTHER
The Affiliated Tumor Hospital of Xinjiang Medical University
UNKNOWN
The First Affiliated Hospital of Anhui Medical University
OTHER
Tianjin Medical University Cancer Institute and Hospital
OTHER
Renmin Hospital of Wuhan University
OTHER
Lili
OTHER
Responsible Party
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Lili
Associate Chief Physician
Central Contacts
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References
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Takayanagi D, Hirose S, Kuno I, Asami Y, Murakami N, Matsuda M, Shimada Y, Sunami K, Komatsu M, Hamamoto R, Kato MK, Matsumoto K, Kohno T, Kato T, Shiraishi K, Yoshida H. Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix. Cancers (Basel). 2021 Mar 10;13(6):1215. doi: 10.3390/cancers13061215.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vladareanu EM, Berceanu C, Ducu I, Iordache AM. Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract. Medicina (Kaunas). 2021 Dec 7;57(12):1338. doi: 10.3390/medicina57121338.
Xu F, Yu Q, Wan D, Zhang Y. Cervical adenocarcinoma admixing with large cell neuroendocrine carcinoma: A rare case report. Asian J Surg. 2022 Dec;45(12):2932-2933. doi: 10.1016/j.asjsur.2022.06.109. Epub 2022 Jun 29. No abstract available.
Salvo G, Gonzalez Martin A, Gonzales NR, Frumovitz M. Updates and management algorithm for neuroendocrine tumors of the uterine cervix. Int J Gynecol Cancer. 2019 Jul;29(6):986-995. doi: 10.1136/ijgc-2019-000504.
Lee E, Ji YI. Large Cell Neuroendocrine Carcinoma of the Cervix with Sequential Metastasis to Different Sites: A Case Report. Case Rep Oncol. 2018 Oct 23;11(3):665-670. doi: 10.1159/000493912. eCollection 2018 Sep-Dec.
Caruso G, Sassu CM, Tomao F, Di Donato V, Perniola G, Fischetti M, Benedetti Panici P, Palaia I. The puzzle of gynecologic neuroendocrine carcinomas: State of the art and future directions. Crit Rev Oncol Hematol. 2021 Jun;162:103344. doi: 10.1016/j.critrevonc.2021.103344. Epub 2021 Apr 29.
Other Identifiers
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TJ-IRB202506084
Identifier Type: -
Identifier Source: org_study_id
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