Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial Hyperplasia
NCT ID: NCT01273636
Last Updated: 2011-01-10
Study Results
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Basic Information
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UNKNOWN
100 participants
OBSERVATIONAL
2005-01-31
2011-06-30
Brief Summary
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Method: Seventy-seven patients who received hysterectomy for endometrial hyperplasia were enrolled and divided into the non-endometrial carcinoma group (57) and the endometrial carcinoma group (20) depending on the final pathology. Clinical variables were analyzed.
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Detailed Description
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Depending on the final pathologic reports of hysterectomy, we divided the seventy-seven patients into two groups - the non-endometrial carcinoma group and the endometrial carcinoma group. Fifty-seven of the studied patients were in the non-endometrial carcinoma group and twenty were in the endometrial carcinoma group. As already mentioned above, we investigated them by clinical parameters including age, menopausal status, obstetrical history, medical history of diabetes and hypertension, BMI (body mass index) and preoperative pathology of D\&C.
The clinical and pathologic characteristics of the twenty patients diagnosed as having endometrial carcinoma postoperatively were also reviewed. Initial manifestation, histological grading of the carcinoma, the depth of myometrial invasion, with or without adjuvant radiotherapy and recurrence were included. The histological grading of endometrial carcinoma was based on FIGO ( International Federation of Gynecology and Obstetrics ) definitions. The BMIs of the patients with endometrial carcinoma were also analyzed by the receiver operating characteristic curve. The Research and Ethics Committee of National Taiwan University Hospital approved this study.
Statistical analyses were performed with the Independent-Samples T test and the Mann-Whitney test. Subsequently, multivariate analysis of risk factors was also employed with Binary logistic regression model to obtain the adjusted odds ratio (OR) and 95% confidence interval (CI) for selective variables. P\<0.05 was defined as significant.
Conditions
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Study Design
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CASE_ONLY
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
30 Years
70 Years
FEMALE
No
Sponsors
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National Taiwan University Hospital
OTHER
Responsible Party
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National Taiwan Unviersity Hospital
Principal Investigators
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Chi An Chen, M.D.
Role: STUDY_CHAIR
Department of Obstetrics and Gynecology, National Taiwan University Hospital
Locations
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Chi-An Chen
Taipei, Taiwan, Taiwan
Chi-An Chen
Taipei, , Taiwan
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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200712018R
Identifier Type: -
Identifier Source: org_study_id
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