Analysis of the Pulmonary Microbiome

NCT ID: NCT06274931

Last Updated: 2024-02-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-02-01

Study Completion Date

2024-06-20

Brief Summary

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The purpose of the protocol is to study the pulmonary microbiome in patients who develop pneumonia.

Detailed Description

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The purpose of the protocol is to study the pulmonary microbiome in patients who develop pneumonia with severe acute respiratory failure, requiring admission to the Intensive Care Unit, and to compare it with that of patients diagnosed with pneumonia but who do not develop severe acute respiratory failure and subsequent admission to the intensive care unit.

Conditions

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Pneumonia Microbial Colonization Microbial Disease

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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ICU patients

Patients admitted to the Intensive Care Unit with a diagnosis of acute respiratory failure

Bronchoscopy

Intervention Type PROCEDURE

Through a bronchoscopic examination performed at the time of admission for diagnostic purposes, an alveolar bronchial lavage was performed for the analysis of the lung microbiome.

non ICU patients

Outpatient patients with a diagnosis of pneumonia

Bronchoscopy

Intervention Type PROCEDURE

Through a bronchoscopic examination performed at the time of admission for diagnostic purposes, an alveolar bronchial lavage was performed for the analysis of the lung microbiome.

Controls

In the control group, an alveolar bronchial lavage was performed directly on lung tissue taken from deceased individuals who did not have any known lung pathologies.

No interventions assigned to this group

Interventions

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Bronchoscopy

Through a bronchoscopic examination performed at the time of admission for diagnostic purposes, an alveolar bronchial lavage was performed for the analysis of the lung microbiome.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with acute respiratory failure
* Patients with suspect of pneumonia

Exclusion Criteria

* pregnancy
* age \< 18 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Magna Graecia

OTHER

Sponsor Role lead

Responsible Party

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Andrea Bruni

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Andrea Bruni

Role: PRINCIPAL_INVESTIGATOR

Magna Graecia University

Locations

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University Hosp[ital

Catanzaro, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Andrea Bruni

Role: CONTACT

3401414553

Facility Contacts

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Andrea Bruni

Role: primary

3401414553

Other Identifiers

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373

Identifier Type: -

Identifier Source: org_study_id

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