Microecology and Host Immunity in Patients With Severe COVID-19 Infection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-12-01

Study Completion Date

2023-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study was to analyze the relationship between the microbial community, host immunity and the prognosis of patients with severe COVID-19.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study

NCT06114784

Severe Pneumonia

RECRUITING

The Association Mechanism Between the Microbiome and the Development of Community Pneumonia Was Studied Based on the Analysis of Pulmonary Microbiota - Host Interaction Network

NCT06896019

Community Pneumonia

ACTIVE_NOT_RECRUITING

Bacterial and Fungal Microbiota of Patients With Severe Viral Pneumonia With COVID-19

NCT04359706

Sars-CoV2

COMPLETED

Development and Qualification of Methods for Analyzing the Mucosal Immune Response to COVID-19

NCT06142279

Certain Disorders Involving the Immune Mechanism

NOT_YET_RECRUITING NA

Study on Immune Status of Patients With COVID-19

NCT05682573

COVID-19 Immunity Life Quality

UNKNOWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Methods: Bronchoalveolar lavage specimens of patients with severe COVID-19 were collected and studied to analyze the relationship between the composition of patients' microecology and the occurrence and development of disease.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Microbiome,Immune Function, Critically Ill

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 1\) Respiratory distress, respiratory rate ≥ 30 times/minute

2\) At rest, oxygen saturation ≤ 93%

3）PaO2/FiO2 ≤300mmHg

4\) Shock

5\) Respiratory failure requires mechanical ventilation

6\) Complicated with other organ failure requires ICU monitoring and treatment

7\) Or in case of any of the following conditions, even if none of the above conditions is found, it is also managed as a critical case: ① pulmonary imaging shows that the lesion has significantly progressed more than 50% within 24-48 hours; ② Age\>60 years old; ③ Complicated with serious chronic diseases (including diabetes, hypertension, coronary heart disease, malignant tumor, structural lung disease, pulmonary heart disease and immunosuppressed population)

Exclusion Criteria

* 1\) Pregnant women

2\) Age\<18

3\) Mental disorders

4\) Patients with long-term mechanical ventilation for more than 60 days

5\) Disagreement group researcher

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No