Clinical Risk Scores in Prediction Outcome of Acute UGIT Bleeding in Non Cirrhotic Patients

NCT ID: NCT06254352

Last Updated: 2024-02-12

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-03-01
• Study Completion Date: 2024-11-30

Brief Summary

To compare the ability of 4 bleeding risk scoring systems (Glasgow -Blatchford score, MAP, H3B2 and ABC scores ) in prediction of: Need of intervention, Re bleeding, Thirty-day mortality, length of hospital stay

Detailed Description

Acute upper gastrointestinal bleeding (UGIB) is a common medical emergency which has a variceal and non-variceal etiology. The non variceal etiology has higher incidence in many countries. In Egypt, non-variceal causes ranged from 26.1% to 61.6% among UGIB cases presented to the emergency departments of different University Hospitals. Guidelines recommend risk stratification early in the management of patients with acute UGIB to help triage patients into the appropriate level of care. Many scoring systems for UGIB were developed and validated from 1990s onwards. Their primary aim was to segregate the patients into low-risk and high-risk groups. High risk patients with UGIB includes those who reach some or all of the endpoints: requirement of blood transfusion, endo-therapeutic, surgical or radiological intervention to achieve hemostasis, re bleeding and mortality. Unfortunately, no single risk score has been shown to be accurate at measuring all relevant outcomes.

The most widely used score is Glasgow Blatchford "GBS" which is a pre endoscopic score. It is useful in prediction of therapeutic intervention for bleeding. More recently, other scores have been developed as ABC score which showed good performance for predicting mortality. MAP score highly predicted therapeutic intervention and mortality. H3B2 score predicted the need of urgent hemostasis.

Limited data are available on the validity of the new scoring systems in predicting the outcome of Egyptian non-cirrhotic patients with acute UGIB. Therefore, The investigators will conduct our study to shed some light on this topic.

Conditions

Upper GI Bleeding

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

scoring system

Clinical Risk Scores in Prediction of Outcome of Acute Upper Gastrointestinal Bleeding in Non Cirrhotic Patients.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Adult non cirrhotic patients
• patients more than 18 years old
• Hematemesis or coffee grounds vomiting.
• Melena with or without hematemesis.
• Blood in nasogastric tube in emergency unit.

Exclusion Criteria

• Patients younger than 18 years old.
• Patients known to be cirrhotic.
• Patients presented with GIT bleeding but refuse to be examined by GIT endoscopy.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Ahmed Gamal Abd Elaal

principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Ahmed Gamal Abd elaal, resident doctor

Role: CONTACT

ahmed.sun1234@gmail.com

01010995958

Ghada Mustafa Kamal, professor

Role: CONTACT

G.refat@aun.edu.eg

01002623401

References

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Reference Type: BACKGROUND

PMID: 24267496 (View on PubMed)

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Reference Type: BACKGROUND

PMID: 21980783 (View on PubMed)

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

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Reference Type: BACKGROUND

PMID: 32723845 (View on PubMed)

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Reference Type: BACKGROUND

PMID: 35820868 (View on PubMed)

Other Identifiers

non variceal UGIT bleeding

Identifier Type: -

Identifier Source: org_study_id