Antibiotic Therapy Practices for Ventilator-Associated Pneumonia (PETUNIA)

NCT ID: NCT06243094

Last Updated: 2024-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1060 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-12

Study Completion Date

2025-03-12

Brief Summary

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The French Society of Intensive Care conducts a comprehensive assessment of current antibiotic therapy practices in critically ill patients suspected of Ventilator-Associated Pneumonia (VAP).

Detailed Description

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This prospective observational multicenter study will be conducted in intensive care units (ICU) across France and French-speaking regions. The primary objective of this study is to delineate the characteristics of antibiotic treatments administered for a first episode of suspected VAP. Secondary objectives include describing the outcomes of enrolled patients, assessing adherence to European guidelines regarding empirical antibiotic treatment, and identifying factors associated with mortality in patients with microbiologically confirmed VAP.

Conditions

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Ventilator Associated Pneumonia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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microbiologically confirmed VAP

patients who meet ATS/IDSA 2005 VAP criteria with microbiological confirmation

Antibiotic

Intervention Type DRUG

All antibiotic therapy characteristics are monitored.

non microbiologically confirmed VAP

patients who do not meet ATS/IDSA 2005 criteria with microbiological confirmation

Antibiotic

Intervention Type DRUG

All antibiotic therapy characteristics are monitored.

Interventions

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Antibiotic

All antibiotic therapy characteristics are monitored.

Intervention Type DRUG

Other Intervention Names

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antimicrobial therapy

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Admission to the ICU
* Intubation and duration of invasive mechanical ventilation \> 48 hours
* Initiation of new antibiotic therapy to treat a first suspicion of Ventilator-Associated Pneumonia (VAP)

Exclusion Criteria

* Presence of a decision to limit active therapeutic measures at the time of initiating antibiotic therapy
* Organ donor
* Prior inclusion in the study during a previous stay in the intensive care unit (a patient cannot be included multiple times)
* Participation in an interventional study focusing on the management of VAP and directly impacting antibiotic therapy practices
* Patient and/or family opposition to participation
* Lack of affiliation with a social security system
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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French Society for Intensive Care

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anahita Rouzé, MD

Role: PRINCIPAL_INVESTIGATOR

French Intensive Care Society

Locations

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Lille university hospital

Lille, Haut de France, France

Site Status RECRUITING

Countries

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France

Central Contacts

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Anahita Rouzé, MD

Role: CONTACT

0033 3 20 44 40 84

Facility Contacts

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Anahita Rouzé, MD

Role: primary

Other Identifiers

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2023-A01492-43

Identifier Type: -

Identifier Source: org_study_id

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