Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
30 participants
INTERVENTIONAL
2024-03-15
2024-04-05
Brief Summary
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Bone particles were harvested during dental implant surgery using low-speed drilling and high speed drilling. After the osteoblasts were cultured, cell proliferation, migration, mineralization, transcription of osteogenesis-related genes, secretion of osteogenesis-related proteins, and osteoinductive protein content in the bone particle matrix were evaluated
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Detailed Description
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In each patient, the conventional high-speed milling protocol with irrigation using physiological saline will be employed in one hemimandible. In the other hemimandible, the implant osteotomy will be performed using a low-speed milling protocol without irrigation.
The milling sequence for the conventional high-speed milling protocol with irrigation will be as follows: the osteotomy will be initiated with a 2.0 mm diameter marking drill, followed by a pilot drill of the same diameter. Subsequently, drills of 2.6/3.2/ and 3.6 mm diameters will be used consecutively. All drills will be used at a speed of 800 rpm and at a depth of 10 mm.
On the other hand, the milling sequence for the low-speed milling protocol without irrigation will be the same, but all drills will be used at a speed of 50 rpm (at the same depth of 10 mm). Finally, once the dental implant and closing screw are inserted, the mucoperiosteal flap will be sutured with simple stitches using synthetic polyamide suture, without immediate prosthetic loading. In all cases, postoperative medication will include 500 mg/8 h amoxicillin for 7 days (in cases of penicillin allergy, 300 mg/8 h clindamycin for 7 days), and 600 mg/8 h ibuprofen for 3 days.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Control group
High speed drilling (800 rpm) with irrigation
High speed drilling with irrigation
High-speed drilling (800 rpm) irrigation to perform the osteotomy
Test group
Low speed drilling (50 rpm) without irrigation
Low speed drilling without irrigation
Low-speed drilling (50 rpm) irrigation to perform the osteotomy
Interventions
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Low speed drilling without irrigation
Low-speed drilling (50 rpm) irrigation to perform the osteotomy
High speed drilling with irrigation
High-speed drilling (800 rpm) irrigation to perform the osteotomy
Eligibility Criteria
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Inclusion Criteria
* Informed consent signed
* Bilateral mandibular dental absence of 3.6 and 4.6 for more than 3 months
* Normal bone density in the posterior mandibular sector with type II/III bone (range of 500-850 HU) according to the classification of Norton and Gamble
* No medical contraindications for the performance of oral surgical procedures (ASA I/II).
Exclusion Criteria
* Presence of any severe mental disorder
* Patients who have undergone head and neck radiotherapy in the previous 18 months.
18 Years
ALL
Yes
Sponsors
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Universidad de Murcia
OTHER
Responsible Party
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Other Identifiers
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26302019
Identifier Type: -
Identifier Source: org_study_id
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