Epstein-Barr Virus and Cancer Risks

NCT ID: NCT06203314

Last Updated: 2024-01-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

100000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-08-01

Study Completion Date

2030-12-31

Brief Summary

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The goal of this prospective cohort study is to investigate the associations between Epstein-Barr Virus (EBV) antibody levels and the risk of overall and site-specific cancer types in Southern China. The main questions it aims to answer are:

Question 1: In addition to the established EBV-associated cancer types, such as lymphomas, nasopharyngeal carcinoma, and stomach cancer, whether EBV is associated with other cancer types? Question 2: What's the cancer burden attributed to EBV in Southern China?

Detailed Description

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Growing molecular evidence suggests the involvement of EBV in various cancers, however, comprehensive epidemiological evidence is still lacking. In this study, researchers conducted a population-based prospective cohort study to investigate the associations between EBV antibodies and the risk of overall and site-specific cancer types in Southern China. All the participants underwent EBV antibody tests at enrollment and were subsequently followed up annually for cancer incidence, vital status, and immigration status. The primary objective of this study was to provide prospective evidence for the role of EBV in multiple cancers, shedding light on the etiology of a broad range of common EBV-associated cancers.

Conditions

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Cancer

Study Design

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Study Time Perspective

PROSPECTIVE

Study Groups

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Zhongshan cohort, Guangdong, China

30-59 years old healthy participants in Zhongshan city.

Diagnostic test: EBV antibody tests

Intervention Type OTHER

Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.

Wuzhou cohort, Guangxi, China

30-69 years old healthy participants in Wuzhou city.

Diagnostic test: EBV antibody tests

Intervention Type OTHER

Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.

Interventions

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Diagnostic test: EBV antibody tests

Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Subject residents in Zhongshan or Wuzhou City;
* Subject has no medical record of prevalent cancer;
* Subject has psychical condition and well consciousness, and willingness to accept and cooperate with the study\'s follow-up procedures.

Exclusion Criteria

* Subject has heavy cardiovascular, liver, or kidney disease;
* Subject has prevalent cancer.
Minimum Eligible Age

30 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wuzhou Red Cross Hospital

OTHER

Sponsor Role collaborator

Zhongshan People's Hospital, Guangdong, China

OTHER

Sponsor Role collaborator

Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

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Jia wei-hua

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zhongshan People's Hospital

Zhongshan, Guangdong, China

Site Status RECRUITING

Wuzhou Red Cross Hospital

Wuzhou, Guangxi, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Wei-Hua Jia

Role: CONTACT

86+020-87342327

Yong-Qiao He

Role: CONTACT

86+020-87342410

Facility Contacts

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Ming-Fang Ji

Role: primary

86+0760-88822698

Min-Zhong Tang

Role: primary

86+0774-3849595

Other Identifiers

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EBV-PRO-001

Identifier Type: -

Identifier Source: org_study_id

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