Accuracy of IVCCI as a Measure of CVP

NCT ID: NCT06166875

Last Updated: 2025-05-07

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 160 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-09-15
• Study Completion Date: 2025-04-30

Brief Summary

The primary aim of the current study is to examine the accuracy of IVCCI for measurement of CVP and to derive equation or formula to predict CVP from IVCCI.

Detailed Description

Hemodynamic monitoring is important in the management of patients in the intensive care unit (ICU) Assessment of the intravascular volume, infusion of fluids or vasoactive drugs and maintenance of an adequate systemic perfusion is essential for reduction of the risk of organ failure and/or mortality.

The use of CVP through central venous catheter is a gold standard method that is extensively used in the ICU as it reflects the filling pressure of the right ventricle (RV) and RV preload.

Central venous cannulation has significant complications such as pneumothorax, hemothorax, arterial puncture, catheter malposition, cardiac arrhythmias, venous embolism, subcutaneous hematoma, and catheter related infection, and it is difficult to use this method in an emergency situation as it requires skilled personnel.

Measurement of IVC index by bedside ultrasound is widely used to assess the intravascular volume in adult patients and has the advantage of being non-invasive, rapid, and reliable for assessing the volume status.

Besides, related measures such as IVC diameter, IVC collapsibility, and IVC to aorta (AO) diameter have been applied clinically to assess the volume status and have been related to CVP.

Conditions

IVC Collapsibility Index

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Derivation Sample

80 patients will be recruited as a derivation sample to calculate the regression equation

No interventions assigned to this group

Validation Sample

80 patients will be recruited as a validation sample to test the performance of the equation

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Age: ≥18 years.
• Sex: Both sexes.
• BMI: <35
• Patient in whom central venous cannulation is needed for management.
• Spontaneously breathing patients.

Exclusion Criteria

• Patients with increased intra abdominal pressure.
• Patients who not able to lie supine.
• Patients on mechanical ventilation.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Ain Shams University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Department of Anesthesiology, Intensive Care, and Pain Management, Faculty of Medicine, Ain Shams University

Cairo, Cairo Governorate, Egypt

Countries

Egypt

Other Identifiers

MD186/2023

Identifier Type: -

Identifier Source: org_study_id