Study of the Research Medicine CIN-103 in Adults With Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D).

NCT ID: NCT06153420

Last Updated: 2025-12-15

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 421 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-12-28
• Study Completion Date: 2025-07-28

Brief Summary

The goal of this clinical trial is to evaluate if the study drug, CIN-103, can help reduce the symptoms associated with irritable bowel syndrome with predominant diarrhea (IBS-D) in adult patients. The main questions it aims to answer are:

• To evaluate the efficacy of CIN-103 on symptoms of IBS-D when given to patients with IBS-D compared to a placebo.
• To evaluate the safety and tolerability of CIN-103 when given to patients with IBS-D compared to a placebo

Participants will attend the following visits:

• Screening Period (1 Visit)
• Baseline Period (1 Visit)

• Will complete daily diary and other Patient Reported Outcomes (PROs) as described in the protocol to assess eligibility for continued participation.
• 12-Week Treatment Period (5 Visits)

• Study drug taken twice daily by mouth.
• Will complete daily diaries and other PROs as described in the protocol.
• Follow- Up Period (1 Visit)

Researchers will compare CIN-103 Dose 1, CIN-103 Dose 2, and placebo, to evaluate the clinical response to multiple dose strengths of CIN-103 relative to placebo on abdominal pain and stool consistency along with safety and tolerability.

Conditions

Irritable Bowel Syndrome With Diarrhea

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

CIN-103 BID Dose 1

CIN-103 Dose 1, administered as 2 x CIN-103 capsules and 2 x matching placebo per dose. Two doses per day.

Group Type: EXPERIMENTAL

CIN-103

Intervention Type: DRUG

CIN-103 BID

CIN-103 BID Dose 2

CIN-103 Dose 2, administered as 4 x CIN-103 capsules per dose. Two doses per day.

Group Type: EXPERIMENTAL

CIN-103

Intervention Type: DRUG

CIN-103 BID

Placebo for CIN-103 BID

Placebo for CIN-103, administered as 4 x matching placebo capsules per dose. Two doses per day.

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DRUG

Placebo for CIN-103 BID

Interventions

CIN-103

CIN-103 BID

Intervention Type: DRUG

Placebo

Placebo for CIN-103 BID

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Are adult male and female subjects ≥ 18 years of age;

2. Have a body mass index between 18 and 45 kg/m2, inclusive at Screening;

3. Meet Rome IV Criteria for IBS-D by subject self-report of recurrent abdominal pain that is associated with ≥ 2 of the following over the last ≥ 6 months, with frequency of at least 1 day per week over the last 3 months (on average) before enrollment:

1. Related to defecation;

2. Associated with a change in frequency of stool; and/or

3. Associated with a change in form (appearance of stool).

4. Based on Investigator interview of subject's symptoms over the last 3 months, have ≥ 25% of bowel movements (BMs) with Bristol Stool Scale (BSS) Type 6 or 7 (loose or watery stools) and < 25% of BMs with BSS Type 1 or 2 (lumpy or hard stools) per the Rome IV Criteria for IBS-D;

5. In the opinion of the Investigator, are on a stable diet for ≥ 4 weeks prior to Screening and are not planning to change lifestyle, exercise, and/or diet that may impact symptoms of IBS-D during study participation;

6. Have a fecal calprotectin ≤ 100 mcg/g at the Screening Visit or Visit 2; Note: A single normal test result is adequate for study eligibility. If subjects are rescreened within 12 months, there is no need for repeat fecal calprotectin sample collection and testing. However, subjects who fail screening due to a fecal calprotectin level > 100 mcg/g are not eligible for re-screening. Note: Repeat Fecal calprotectin may be considered with prior Sponsor approval.

7. Have a serum tTG-IgA (tissue transglutaminase immunoglobulin A) ≤ 4.99 FLU (fluorescent light units) at the Screening Visit;

8. Have undergone a colonoscopy examination within the designated time interval prior to randomization, if they meet any of the following criteria. Note: A negative Cologuard® test result is an acceptable alternative to colonoscopy for subjects ≥ 45 years and at average risk for colon cancer.

1. Average risk, based on US Preventive Services Task Force Recommendation Statement for screening of colorectal cancer, with age ≥ 45 years (colonoscopy within 10 years or negative test results on Cologuard within 3 years);

2. Personal history of completely removed adenomatous colorectal polyps (colonoscopy within 5 years for polyps > 1 cm, within 10 years for polyps < 1 cm);

3. History of colorectal cancer or adenomatous polyps in a first-degree relative before age 60 (colonoscopy within 5 years); or

4. History of colorectal cancer or adenomatous polyps in ≥ 2 first-degree relatives at any age, or family history of hereditary colorectal cancer or polyposis (colonoscopy within 5 years).

Exclusion Criteria

1. Have a diagnosis or suspected diagnosis of non-diarrhea predominant IBS (eg, IBS with a subtype of constipation, IBS with mixed or alternating bowel habits, un-subtyped IBS) or functional constipation by the Rome IV Criteria;

2. Non-infectious chronic lower gastrointestinal conditions including a history of or current inflammatory bowel disease (ie, Crohn's disease, ulcerative colitis, indeterminate colitis), recurrent diverticulitis, microscopic colitis, lymphocytic colitis, celiac disease, non-celiac gluten sensitivity and non-compliant on a gluten-free diet, untreated lactose intolerance, carcinoid syndrome, Lynch syndrome, or familial polyposis, intestinal obstruction, stricture, toxic megacolon, solitary rectal ulcer syndrome, GI perforation, intra-abdominal or pelvic adhesions, ischemic colitis, radiation proctitis, chronic enteritis, non-infectious colitis, or impaired intestinal circulation (eg, aortoiliac disease);

Note: Lactose intolerance and non-celiac gluten sensitivity will not exclude a subject from participation if the Investigator documents that the subject is compliant on a special diet (lactose-free diet or gluten-free diet, respectively) and/or for lactose intolerance is successfully treated with commercial lactase supplement(s).

3. Infectious lower gastrointestinal conditions requiring antibiotics or microbiome therapy; any microbiologically documented acute lower gastrointestinal colitis or enteritis requiring antibiotic treatment including successfully treated Clostridioides difficile colitis within 3 months prior to Screening, or a history of recurrent C. difficile colitis at any time in the past;

4. Have a known family history of inflammatory bowel disease in at least 1 first-degree relative;

5. Have a known history of a pelvic floor disorder associated with constipation (unless successful treatment has been documented by a normal balloon expulsion test or anorectal manometry), refractory constipation not responsive to standard medical therapy, fecal impaction that required hospitalization, cathartic colon, and/or active proctological condition;

6. Have a history of or current non-IBS chronic condition(s) with ongoing symptoms associated with abdominal pain or GI discomfort (eg, gastroparesis, functional dyspepsia, uncontrolled gastroesophageal reflux disease, polycystic kidney disease, ovarian cysts, urological pain, or endometriosis);

7. Have a history of or current clinically significant arrhythmias as judged by the Investigator, including ventricular tachycardia, ventricular fibrillation, and Torsades de pointes. Subjects with any abnormal electrocardiogram (ECG) not considered clinically significant by the Investigator are not excluded;

8. Have current or a history of diverticulitis, heme positive stool, or unexplained GI bleeding within 3 months prior to Screening.

Note: Surgically repaired diverticulitis > 3 months prior to Screening is permitted.

9. Have a history of surgical resection of the stomach, small, or large intestine;

10. Have had any major abdominal surgery within the 3 months prior to Screening;

Note: Permitted procedures are uncomplicated appendectomy, cholecystectomy, and resection of benign polyps within the 3 months prior to Screening. Subjects who had an appendectomy that was associated with any related complications or sequelae are eligible if the procedure was performed at least 6 months prior to Screening.

11. Are currently undergoing or planning to initiate treatment with weight loss medication during study participation or prior weight loss surgery (eg, gastric bypass surgery, gastric banding);

12. Have a planned invasive elective surgery during the period of anticipated study participation from the time of informed consent through the last study visit;

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

CinPhloro Pharma, LLC

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Digestive Health Specialists - Dothan

Dothan, Alabama, United States

Clinical Research Associates, LLC

Huntsville, Alabama, United States

Elite Clinical Studies LLC

Phoenix, Arizona, United States

GI Alliance - Sun City

Sun City, Arizona, United States

Applied Research Center of Arkansas

Little Rock, Arkansas, United States

Paragon Rx Clinical, Inc. - Garden Grove

Garden Grove, California, United States

Gastro Care Institute- lancaster

Lancaster, California, United States

Medical Associates Research Group

San Diego, California, United States

American Family Research Group

Cape Coral, Florida, United States

USA and International Research Inc.

Doral, Florida, United States

International Research Associates LLC

Miami, Florida, United States

Innovation Medical Research Center

Palmetto Bay, Florida, United States

Velocity Clinical Research,, Savannah

Savannah, Georgia, United States

Southwest Gastroenterology

Oak Lawn, Illinois, United States

DelRicht Research

Mandeville, Louisiana, United States

Tandem Clinical Research GI LLC

Marrero, Louisiana, United States

Tandem Clinical Research GI LLC

Metairie, Louisiana, United States

DelRicht Research

New Orleans, Louisiana, United States

Delta Research Partners, LLC

West Monroe, Louisiana, United States

DelRicht Research of Bethesda Clinical Trials

Rockville, Maryland, United States

St. Charles Clinical Research

Weldon Spring, Missouri, United States

Quality Clinical Research, Inc

Omaha, Nebraska, United States

Las Vegas Medical Research

Las Vegas, Nevada, United States

Digestive Disease Specialists

Las Vegas, Nevada, United States

Advanced Research Institute - Reno

Reno, Nevada, United States

Allied Digestive Health Clinical Research Organization

Somers Point, New Jersey, United States

Allied Digestive Health-Jersey Shore Gastroenterology - Point Commons

Somers Point, New Jersey, United States

Albuquerque Clinical Trials, Inc

Albuquerque, New Mexico, United States

Westchester Putnam Gastro

Carmel Hamlet, New York, United States

IMA Clinical Research PC and Affiliates- New York, NY

New York, New York, United States

NY Scientific

New York, New York, United States

Atrium Health - Center for Gastroenterology and Hepatology MMP

Charlotte, North Carolina, United States

Peters Medical Research

High Point, North Carolina, United States

IMA Clinical Research

Mount Airy, North Carolina, United States

Cleveland Clinic

Cleveland, Ohio, United States

Remington Davis, Inc.

Columbus, Ohio, United States

Great Lakes Gastroenterology Research LLC

Mentor, Ohio, United States

Northshore Gastroenterology Research, LLC

Westlake, Ohio, United States

Options Health Research LLC

Tulsa, Oklahoma, United States

Susquehanna Research Group, LLC

Harrisburg, Pennsylvania, United States

DelRicht Research of Charleston Clinical Trials

Charleston, South Carolina, United States

Palmetto Clinical Research

Summerville, South Carolina, United States

Galen Medical Group - Downtown Gastroenterology Location

Chattanooga, Tennessee, United States

Tri-Cities Gastroenterology

Kingsport, Tennessee, United States

Advanced Gastroenterology

Union City, Tennessee, United States

The University of Texas Health Science Center at Houston

Bellaire, Texas, United States

The Clinical Trials Network LLC

Houston, Texas, United States

Care and Cure Clinic

Houston, Texas, United States

GLRI - McAllen Research

Pharr, Texas, United States

Quality Research Inc

San Antonio, Texas, United States

Gastroenterology Research of San Antonio

San Antonio, Texas, United States

Advanced Research Institute

Ogden, Utah, United States

GI Alliance - Washington Gastroenterology

Tacoma, Washington, United States

Countries

United States

Other Identifiers

CIN-103-121

Identifier Type: -

Identifier Source: org_study_id