Dermogenesis With Mesenchymal Stem Cells

NCT ID: NCT06135519

Last Updated: 2024-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-23

Study Completion Date

2024-02-22

Brief Summary

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Dermogenesis With Mesenchymal Stem Cells in treating Post Acne Depressed Spots

Detailed Description

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management at two different stages of the course of the disease. First one at the stage of active disease which needs cleansers, antibiotics, retinoids, anti inflammatory agents and hormonal manipulation. Once active disease is over, patients report to clinician with depressed spots which are caused by localized dermal disruption and fat atrophy post inflammation or spontaneous epithelial rupture or scratching by the patient. These acne spots are hard to treat due to many reasons. Firstly, excision is difficult as size of most of them is small and they are in a large in number. Secondly, filling with and without subcision is not adequately addressing the deformity. Currently, a combination of filling with synthetic filler or fat and resurfacing by peeling, LASER or dermabrasion is in practice. In-spite of all, a treatment is still required to address post acne spots (Ice Spec Spots) adequately.

Conditions

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Dermal Regeneration

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Group A with MSCs Group B with Fat
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mesenchymal stem cells

Mesenchymal Stem Cells taken from adipose tissue will be used

Group Type EXPERIMENTAL

Autologous Mesenchymal stem cells injection

Intervention Type PROCEDURE

Autologous Mesenchymal stem cells will be seperated from harvested fat and injected in acne scars

Homogenized fat

Adipose tissue will be harvested and used

Group Type EXPERIMENTAL

Homogenized fat injection

Intervention Type PROCEDURE

Autologous fat will be harvested, homogenized and injected.

Interventions

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Autologous Mesenchymal stem cells injection

Autologous Mesenchymal stem cells will be seperated from harvested fat and injected in acne scars

Intervention Type PROCEDURE

Homogenized fat injection

Autologous fat will be harvested, homogenized and injected.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Acne spots

Exclusion Criteria

* Active acne
Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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King Edward Medical University

OTHER

Sponsor Role lead

Responsible Party

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Afzaal Bajwa

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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King Edward Medical University

Lahore, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

References

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Bashir A, Choudhery MS, Afzaal S, Ali S, Afzaal S. Adipose Tissue-Derived Stem Cells Enhance Dermogenesis of Post-Acne Depressed Spots. J Cosmet Dermatol. 2025 Oct;24(10):e70399. doi: 10.1111/jocd.70399.

Reference Type DERIVED
PMID: 41078325 (View on PubMed)

Other Identifiers

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kemu/23/2

Identifier Type: -

Identifier Source: org_study_id

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