Compined SONOPULMONARY Infection Score and APACHE Score in RICU Patients With VAP

NCT ID: NCT06090032

Last Updated: 2023-10-19

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 53 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-11-01
• Study Completion Date: 2024-12-30

Brief Summary

Aim of the study :

1. Efficacy of Sono pulmonary infection score in combination with APACHE score in early diagnosis of VAP

2. Assessment of prediction role of combined SIPS SCORE and APACHE SCORE of outcome of VAP patient in RICU

3. Assessments of role of ultrasonography in early diagnosis and follow up of VAP

Detailed Description

Pneumonia is a bacterial, viral or fungal infection of the lungs, which causes the alveoli of the lungs to fill up with microorganisms, fluid and inflammatory cells, preventing the lungs from functioning effectively[1]. Ventilator associated pneumonia (VAP) is the most common and a leading cause of death in intensive care unit patient. Ventilator associated pneumonia is caused by prolonged duration of mechanical ventilation ,and prolonged hospital stay, which increase hospital costs, possibly increase mortality rate, and increase antibiotic use in ICU patients , early identification of VAP is an important clinical goal to improve patient outcomes [2]. In recent year several scoring systems have been developed to evaluate the severity of illness and to predict the outcome, especially the mortality rate of intensive care unit patient, such as the Clinical pulmonary infection score (CPIS) or modified (CPIS)The Clinical Pulmonary Infection Score (CPIS) was developed to serves a tool to facilitate the diagnosis of ventilator-associated pneumonia (VAP),The CPIS is calculated on the basis of points assigned for various signs and symptoms of pneumonia (eg, fever and extent of oxygenation mpairment) ,a CPIS has an average between 0-12>6 some studies suggest that CPIS >6 may correlate with VAP Sonar is easy bedside test to diagnose pleural effusion, pneumonia pneumothorax , so recently lung ultrasonography (LUS) incorporated in evaluation and diagnosis of VAP in a new score called sono pulmonary infection score (SPIS) . The (SPIS), where is incorporated LUS finding instead of CXR finding of CPIS is assigned two points for ≥ one area of dynamic air bronchogram. One point was given for ≥ two sub-pleural consolidation or lobar consolidation areas or ≥ one sub-pleural, and ≥one lobar consolidationRecently (combination of SPIS with APACHE score in assessment of VAP is under research ).

Conditions

Respiratory Intensive Care Unit Patients With Ventilator Associated Pneumonia

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Interventions

Ultrasound

We will use ultrasongraphy as a part of assessment in respiratory intensive care unit patients with ventilator associated pneumonia

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Age >18 yrs

2. Mechanically ventilated patients after first 48 hours of admission in RICU

Exclusion Criteria

1. Age <18 yrs

2. Patients already diagnosed pneumonia

3. Malignancy

4. patient refused participation in the study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Lamiaa Hussein Fouda

Doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Lamiaa hussein Fouda, Master

Role: CONTACT

Lamiaahussein5@gmail.com

01140705774

Sahar farghly youssif

Role: CONTACT

Saherfr2009@yahoo.com

+201002976708

Related Links

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8830125/

The National Institute for Health and Care Excellence (NICE), Pneumonia in adults: diagnosis and management. 2019

https://pubmed.ncbi.nlm.nih.gov/20597663/

3\. (Klevens RM, Edwards JR, Richards CL, et al. Estimating health careassociated infections and deaths in U.S. hospitals, 2002, Public Health Rep, 2007, vol. 122 (pg. 160-166).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991773/

4\. Mongodi S, Via G, Girard M, Rouquette I, Misset B, Braschi A et al. Lung ultrasound for early diagnosis of ventilator-associated pneumonia. Chest. 2016;;149((4):969--980.. doi: 10.1016/j.chest.2015.12.012

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225448/

. Knaus WA, Zimmerman JE, Wagner DP, Draper EA, Lawrence DE. APACHE-acute physiology and chronic health evaluation: A physiologically based classification system. Crit Care Med. 1981;9:591-7.

Other Identifiers

Chest U/S in RICU PT WITH VAP

Identifier Type: -

Identifier Source: org_study_id