FilmArray® and Management of Ventilator Associated Pneumonia in COVID-19 ARDS
NCT ID: NCT05076240
Last Updated: 2021-10-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
98 participants
OBSERVATIONAL
2021-03-27
2021-04-30
Brief Summary
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VAPs complicate about 40-50% of COVID-19 acute respiratory distress syndrome (ARDS) and the mortality would be twice higher.
Thus, in this context of the COVID-19 pandemic, this represents a considerable rate of patients.
Unfortunately, the risk factors for VAPs are poorly understood and the bacterial ecology varies around the world. Also, facing a high prevalence of multi-resistant bacteria in this population, the choice of probabilistic antibiotic therapy is complex and represents a considerable impact for care.
New microbiological rapid diagnostic techniques have appeared in recent years, among them the FilmArray® seems to present interesting diagnostic performances with the ability to detects resistance to antibiotics.
This technique has been studied in acute community pneumonia but has not been validated in VAP and even less during the COVID-19 period.
Investigators decide to conduct this study to investigate if the early identification of the pathogens and their mechanism of resistance using FilmArray® would improve the relevance of the antibiotic treatment.
The aim of this project is to evaluate the contribution of a rapid diagnostic technique to the management of Ventilator Associated Pneumonia during COVID-19 acute respiratory distress syndrome before an interventional study.
Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Adults with ventilator associated pneumonia in COVID-19 ARDS
Patient hospitalized in intensive care unit for acute respiratory distress related to a Sars-Cov2 infection having contracted ventilator associated pneumonia. The diagnosis was made by culture but also with a FilmArray® multiplex PCR analysis.
FilmArray® analysis
FilmArray® multiplex PCR analysis to diagnose ventilator associated pneumonia in COVID-19 ARDS
Interventions
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FilmArray® analysis
FilmArray® multiplex PCR analysis to diagnose ventilator associated pneumonia in COVID-19 ARDS
Eligibility Criteria
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Inclusion Criteria
* COVID-19 acute respiratory distress syndrome hospitalization
* affected Ventilator Associated Pneumonia
* having multiplex PCR analysis FilmArray®
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire de Nīmes
OTHER
Responsible Party
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Principal Investigators
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Claire ROGER, MD, PhD
Role: STUDY_DIRECTOR
Centre Hospitalier Universitaire de Nîmes
Locations
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CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, , France
Countries
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Other Identifiers
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LOCAL/2021/LD-01
Identifier Type: -
Identifier Source: org_study_id