Microbiota and Metabolomics of Intestinal Type of Gastric Cancer

NCT ID: NCT06079554

Last Updated: 2024-04-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

32 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-31

Study Completion Date

2025-08-30

Brief Summary

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Compare with the gastric cavity without cancerous transformation in atrophic gastritis, analyze the microbiota and metabolomics changes in intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.

Detailed Description

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This study adopts a prospective cohort study. The expected recruitment time for all participants is 6 months, and all cases are cases who would receive magnifying endoscopy examination. The extent of atrophy and the presence of early gastric cancer are determined under magnifying endoscopy. Cases are chose into the gastric cancer group and atrophic gastritis group in a 1:1 ratio. There are 16 cases of intestinal type of gastric cancer under the background of atrophic gastritis, and 16 cases of atrophic gastritis without gastric cancer matched according to gender, age, and degree of gastric atrophy, totaling 32 cases. Analyze the characteristics of early gastric cancer under endoscopy, investigate the changes in microbiota and metabolomics of intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.

Conditions

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Gastric Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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the gastric cancer group

16 cases of intestinal type of gastric cancer under the background of atrophic gastritis

No interventions assigned to this group

the atrophic gastritis group

16 cases of atrophic gastritis without gastric cancer matched according to gender, age, and degree of gastric atrophy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* •Intestinal type of gastric cancer or atrophic gastritis

* Underwent Endoscopic submucosal dissection(ESD)

Exclusion Criteria

* • have simultaneously other cancer

* have severe systemic inflammatory disease ,serious illness such as diabetes, chronic lung diseases
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Jilin University

OTHER

Sponsor Role lead

Responsible Party

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Dong Yang

Assisted Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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the First Hospital of Jilin University

Changchun, Jilin, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Hong Xu, professor

Role: CONTACT

18844097668

Dong Yang, doctor

Role: CONTACT

Facility Contacts

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Dong Yang, Master

Role: primary

Other Identifiers

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130027

Identifier Type: -

Identifier Source: org_study_id

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