A Multi-omics-based Metabolic Typing Study of Gastric Cancer

NCT ID: NCT06134011

Last Updated: 2023-11-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

480 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-10

Study Completion Date

2024-09-10

Brief Summary

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In the study, the investigators obtained gastric cancer tissues from 480 gastric cancer patients who had undergone surgery at the Zhejiang Cancer Hospital's biospecimen bank between 2012-2019, and obtained relevant clinical information. The gastric cancer tissues were subjected to transcriptomic, metabolomic and other multi-omics testing, and analyzed for the metabolic changes of gastric cancer, and proposed to discover relevant therapeutic targets.

Detailed Description

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Conditions

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Gastric Cancer Multi-omics Diagnosis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

OTHER

Study Groups

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Cancer tissues

Without any intervention

Intervention Type OTHER

There were no special interventions for the two groups.

Normal adjacent tissues

Without any intervention

Intervention Type OTHER

There were no special interventions for the two groups.

Interventions

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Without any intervention

There were no special interventions for the two groups.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18≤age≤80
* Histologically or cytologically confirmed gastric cancer
* Undergo surgery for radical or palliative gastric cancer (both open and laparoscopic)
* Patients with survival follow-up information

Exclusion Criteria

* Two or more kinds of malignant tumors at the same time
* Incomplete or missing case information
* Preoperative diagnosis of residual gastric cancer
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Zhejiang Cancer Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xiangdong Cheng

Secretary of the party committee

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

Hangzhou, Zhejiang, China

Site Status

Countries

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China

References

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Li S, Yuan L, Xu ZY, Xu JL, Chen GP, Guan X, Pan GZ, Hu C, Dong J, Du YA, Yang LT, Ni MW, Jiang RB, Zhu X, Lv H, Xu HD, Zhang SJ, Qin JJ, Cheng XD. Integrative proteomic characterization of adenocarcinoma of esophagogastric junction. Nat Commun. 2023 Feb 11;14(1):778. doi: 10.1038/s41467-023-36462-8.

Reference Type RESULT
PMID: 36774361 (View on PubMed)

Shi W, Wang Y, Xu C, Li Y, Ge S, Bai B, Zhang K, Wang Y, Zheng N, Wang J, Wang S, Ji G, Li J, Nie Y, Liang W, Wu X, Cui J, Wang Y, Chen L, Zhao Q, Shen L, He F, Qin J, Ding C. Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer. Nat Commun. 2023 Feb 14;14(1):835. doi: 10.1038/s41467-023-35797-6.

Reference Type RESULT
PMID: 36788224 (View on PubMed)

Wang J, Kunzke T, Prade VM, Shen J, Buck A, Feuchtinger A, Haffner I, Luber B, Liu DHW, Langer R, Lordick F, Sun N, Walch A. Spatial Metabolomics Identifies Distinct Tumor-Specific Subtypes in Gastric Cancer Patients. Clin Cancer Res. 2022 Jul 1;28(13):2865-2877. doi: 10.1158/1078-0432.CCR-21-4383.

Reference Type RESULT
PMID: 35395077 (View on PubMed)

Other Identifiers

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IRB-2023-935

Identifier Type: -

Identifier Source: org_study_id

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