Genomic Evolution of Metastasis in Gastric Cancer

NCT ID: NCT05061082

Last Updated: 2022-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-26

Study Completion Date

2022-10-31

Brief Summary

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The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.

Detailed Description

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Gastric cancer is the fourth most common cancer in Vietnam with high mortality rate. Metastasis is the leading cause of death in gastric cancer patients, with median overall survival of less than 1 year. Currently, there is no effective treatment because the molecular mechanism of metastasis remains unclear. The aim of this study is to use advanced NGS technologies to dissect the genomic changes (genetic, epigenetic and transcriptional changes) of the primary tumor and associated metastatic sites of the same patients. With that, the investigators can reconstruct the clonal evolution from primary tumor to metastasis, identify key pathways governing metastasis development that can be targeted for future therapeutic development.

Conditions

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Gastric Cancer Metastasis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. Male or Female patients aged 18 years and older
2. Histologically proven primary gastric adenocarcinoma and clinical evidence of metastasis (N1-3M1)
3. Biopsies can be taken at multiple sites
4. No known other concomitant cancer diagnosis
5. Signed informed consent

Exclusion Criteria

1. Gastric adnocarcinoma cannot be confirmed primary
2. Unable to undergo biopsy or surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Center Ho Chi Minh City (UMC)

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Medical Center Ho Chi Minh City

Ho Chi Minh City, , Vietnam

Site Status RECRUITING

Countries

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Vietnam

Central Contacts

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Long Duy Vo, MD, PhD

Role: CONTACT

+84. 918133915

Facility Contacts

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Long Vo, MD

Role: primary

+84918133915

Other Identifiers

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80/GCN-HDDD 2021

Identifier Type: -

Identifier Source: org_study_id

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