The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-06-01

Study Completion Date

2022-06-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The goal of this observational study is to learn about the association between cardiac valve calcification and the 1-year mortality after lower-extremity amputation in diabetic patients. Diabetic patients requiring lower-extremity amputation were retrospectively studied. Preoperative detailed anamnesis was taken. Cardiac valve calcification was assessed using echocardiography at baseline. One-year follow-up was conducted and included clinical visits, hospital record assessment, and telephone reviews to obtain the survival status of patients. Researchers compare the survival group to the mortality group to study the relationship between the cardiac valve calcification and mortality.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Type II Diabetes Influence on Left Ventricular Remodeling and Outcomes in Patients Undergoing Aortic Valve Replacement Surgery.

NCT01862237

Type II Diabetes

UNKNOWN NA

Multimodal Imaging Evaluation and Prognostic Analysis of Participants After Arterial Switch Operation

NCT04980339

Arterial Switch Operation

NOT_YET_RECRUITING

Evaluation of Systemic Microcirculation of Patients Undergoing Heart Valve Surgery

NCT05728047

Microvascular Rarefaction Heart Valve Diseases Extracorporeal Circulation

COMPLETED

Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention

NCT04407936

Cardio-Renal Syndrome Coronary Angiography Coronary Artery Disease +2 more

COMPLETED

Clinical Trial in China for Aortic Valve Stenosis

NCT05607667

Diseases of Aortic Valve Aortic Stenosis Disease

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation. The investigator recruited consecutive patients who were admitted to the Sun Yat-sen Memorial Hospital for diabetic foot ulcers that needed amputation surgery. Clinical characteristics of each patient and the laboratory examination were collected before surgery. Cardiac valve calcification was assessed at baseline. This study obtained the survival status of patients within one year through outpatient follow-up and telephone follow-up. Researchers compared the survival group to the mortality group to see if the mortality group had a higher prevalence of heart valve calcification.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Amputation Diabetic Foot Valve Disease, Aortic Valve Heart Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

survival group

The patients who survived more than 1-year after amputation surgery.

calcified cardiac valve

Intervention Type OTHER

patients have cardiac cardiac valve before surgery

mortality group

The patients who were dead within 1-year after amputation surgery.

calcified cardiac valve

Intervention Type OTHER

patients have cardiac cardiac valve before surgery

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

calcified cardiac valve

patients have cardiac cardiac valve before surgery

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Had echocardiography at baseline
* With diabetic foot ulcers that required amputation after orthopedist's assessment

Exclusion Criteria

* Fractures due to traumatic reasons that required extremity amputation
* Amputation level below the ankle
* Severe sepsis that required vasoactive agent treatment
* Rheumatic heart disease
* Heart valve surgery history

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No