Prognostic Interest of Vasorin in Septic Shock

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-03

Study Completion Date

2025-03-31

Brief Summary

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In septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe Acute Kidney Injury (AKI). Vasorin (Vasn) is a protein strongly expressed in large vessels and kidneys, whose functions are still poorly known. Previous experimental studies show that Vasn is associated with decreased Angiotensin II concentrations, a vessel contractility defect and early mortality.

The investigators hypothesize that Vasn (the potential direct regulator of blood pressure) would be an early biomarker predicting the severity of AKI post septic shock, which may be associated with mortality from septic shock or lead to longer-term Chronic Renal Failure (CKD).

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Detailed Description

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Conditions

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Sepsis Acute Kidney Injury

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Interventions

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Blood sampling

Blood sampling (at day 0 and day 3) for Vasn, Angiotensin 2 and clotting markers.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years old.
* Hospitalized in intensive care or medical resuscitation units.
* With a septic shock state defined by 2 mmol/l lactate sepsis, requiring vasopressors to maintain mean blood pressure 65 mmHg (despite adequate vascular filling).
* Whether or not they have developed AKI.
* Patient/family information and collection of non opposition

Exclusion Criteria

* Patients with chronic respiratory failure.
* Pregnant women.
* Patients in palliative care.
* Information for the patient/someone close and collection of his opposition

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No