Acute Kidney Dysfunction in COVID-19 and Non-COVID-19 Related ARDS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

130 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-05-02

Study Completion Date

2022-09-01

Brief Summary

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In addition to respiratory involvement, SARS-CoV 2, the virus responsible for coronavirus 2019 or Covid-19, appears to be responsible for renal involvement such as acute renal failure or proteinuria, so the mechanisms are not known at this time. The consequences of Covid-19 on renal function in the short and long term are not known.

It is important to be able to better document these renal impairments to understand the mechanisms of this disease.

The main objective of this study is to describe the prevalence of Covid-19-related renal damage (acute renal failure, proteinuria, microalbuminuria, hematuria) in a large cohort of patients in intensive care for SARS-CoV 2 infection with severe respiratory impairment.

The other objectives will be to evaluate in this cohort the impact of these renal impairments on the severity of the Covid-19 disease, and to compare them to the renal impairments of patients in intensive care for acute respiratory distress syndrome (ARDS) due to other respiratory diseases.

Blood and urine samples will be taken at the time of intubation in all critically ill patients with respiratory distress requiring mechanical ventilation for Covid-19 or other cause of respiratory distress with PaO2/FiO2 ratio \< 300.

Patients will be followed for the duration of their ICU and hospital stay. Data will be collected prospectively in three ICUs in the University Hospitals of Marseille.

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Detailed Description

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Conditions

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COVID-19 Acute Respiratory Distress Syndrome Acute Kidney Injury Due to COVID-19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients in intensive care for SARS-CoV 2 infection with severe respiratory impairment.

Data collection

Intervention Type OTHER

acute kidney injury and tubular dysfunction

Patients in intensive care without SARS-CoV 2 infection with severe respiratory impairment.

Data collection

Intervention Type OTHER

acute kidney injury and tubular dysfunction

Interventions

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Data collection

acute kidney injury and tubular dysfunction

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* • Displaying acute respiratory distress Needing invasive mechanical ventilation

* With PaO2/FiO2 ratio \< 300 after orotracheal intubation

Exclusion Criteria

* Patients in ICU following thoracic surgery or lung transplantation
* Patients with cardiogenic pulmonary oedema
* Patients with end stage kidney disease
* Moribund patients

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No