Serum Free Amino Acid Concentrations in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy (CRRT)

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

26 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-19

Study Completion Date

2022-12-15

Brief Summary

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Sepsis is a life-threatening condition associated with high morbidity and mortality. The breakdown of proteins mainly from skeletal muscles leads to the release of free amino acids (FAAs). The serum FAA pool has been repeatedly assessed and found to be significantly altered in patients with sepsis/septic shock. Sepsis is well known to be the most common factor contributing to the development of acute kidney injury in critically ill patients.

The investigators want to establish the baseline profile of FAAs and their derivatives in patients with sepsis/septic shock undergoing continuous renal replacement therapy due to sepsis-associated acute kidney injury. Secondly, the investigators want to compare the FAA profiles of the survivors and nonsurvivors.

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Detailed Description

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Conditions

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Sepsis Amino Acid Catabolism Disorder

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Survivors

Patients hospitalized in the Department of Anaesthesiology and Intensive Care with sepsis or septic shock, undergoing continuous renal replacement therapy due to acute kidney injury, in whom the outcome of treatment was survival.

Blood sample analysis

Intervention Type DIAGNOSTIC_TEST

The concentrations of AAs and related compounds were determined by liquid chromatography/mass spectrometry (LC/MS)

Nonsurvivors

Patients hospitalized in the Department of Anaesthesiology and Intensive Care with sepsis or septic shock, undergoing continuous renal replacement therapy due to acute kidney injury, in whom the outcome of treatment was fatal.

Blood sample analysis

Intervention Type DIAGNOSTIC_TEST

The concentrations of AAs and related compounds were determined by liquid chromatography/mass spectrometry (LC/MS)

Interventions

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Blood sample analysis

The concentrations of AAs and related compounds were determined by liquid chromatography/mass spectrometry (LC/MS)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* over 18 years of age
* present AKI
* requiring renal replacement therapy
* hospitalized at the ICU.

Exclusion Criteria

* acute kidney disease requiring renal replacement therapy prior to admission to the ICU
* chronic kidney disease requiring renal replacement therapy prior to admission to the ICU
* history of past CRRT.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No