Effects of Home Base Whole-body Vibration in Osteoarthritis. (VIBE-Rx2)

NCT ID: NCT06058169

Last Updated: 2025-10-03

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-04-25
• Study Completion Date: 2026-01-01

Brief Summary

The purpose of this proposal is to understand how the Vibrant Health Ultimate whole-body vibration (WBV) machine affects pain and inflammation in older adults. The investigators' hypothesize that sub-acute (12 weeks) WBV will lead to improvement in the level of knee pain and improve vascular function via a decrease in systemic inflammation.

Detailed Description

Knee osteoarthritis (KO) is a leading cause of disability and medical cost. Whole body vibration (WBV) has emerged as an exercise alternative that may be more tolerable than traditional forms of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise, research supports that WBV can be very beneficial for your health. In fact, a single bout of WBV increases circulating concentrations of inflammatory markers. WBV is safe and effective, WBV training has been conducted in obesity, elderly, patients with diabetes, patients with lung disease, as well as patients with knee osteoarthritis.

Conditions

Whole Body Vibration; Osteo Arthritis Knee

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Whole Body Training (12 week)

Group Type: EXPERIMENTAL

Sub Acute Whole Body Vibration Training

Intervention Type: DEVICE

Participants will be given a personal vibration plate (equipped with stabilizing bars) to take home for training which will last for up 12 weeks. For this test the participant will be asked to stand on a vibration plate for up to 20 minutes. Participants will be instructed to remove any footwear and stand mid-center on the platform in a standing position with feet shoulder width apart. The participant will be asked to step on and off of the vibration plate. During the first four weeks, participants will be asked to complete 5-10 minutes of WBV per day, at least 4-5 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 15 minutes and/or reduce the duration of rest. Beginning at week 9, based on how the participant feels, the study team may adjust the WBV time/duration up to 20 minutes per session, 4-5 days per week.

Interventions

Sub Acute Whole Body Vibration Training

Participants will be given a personal vibration plate (equipped with stabilizing bars) to take home for training which will last for up 12 weeks. For this test the participant will be asked to stand on a vibration plate for up to 20 minutes. Participants will be instructed to remove any footwear and stand mid-center on the platform in a standing position with feet shoulder width apart. The participant will be asked to step on and off of the vibration plate. During the first four weeks, participants will be asked to complete 5-10 minutes of WBV per day, at least 4-5 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 15 minutes and/or reduce the duration of rest. Beginning at week 9, based on how the participant feels, the study team may adjust the WBV time/duration up to 20 minutes per session, 4-5 days per week.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Symptomatic Osteoarthritic knee pain for at least 6 months.
• Mean and women
• Ages 40-75 years old

Exclusion Criteria

• <40 years old or >75 years old
• History of balance issues
• History of falls
• Epilepsy
• Pregnancy
• The use of whole-body vibration in the past 6 months
• Previous knee surgery within last 3 years
• Unable to stand for at least 20 minutes (for whole body vibration training)

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Augusta University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology

Augusta, Georgia, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Reva Crandall, BS

Role: CONTACT

rcrandall@augusta.edu

7067215483

Ryan Harris, PhD

Role: CONTACT

ryharris@augusta.edu

7067215998

Facility Contacts

Ryan Harris, PhD, CEP

Role: primary

ryharris@augusta.edu

706-721-5998

Reva Crandall, BS

Role: backup

rcrandall@augusta.edu

706-721-5483

Other Identifiers

2054289

Identifier Type: -

Identifier Source: org_study_id