Cartilage Adaptation and Response to Interleukins and Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-21

Study Completion Date

2019-09-10

Brief Summary

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This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.

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Detailed Description

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By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis. The collagen formation as well as the effect on the cytokine content of the synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training. Overall the project aims to improve the basic understanding of cartilage development and function in relation to osteoarthritis prevention.

Conditions

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Osteo Arthritis Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Exercise group

Group Type EXPERIMENTAL

Exercise.

Intervention Type BEHAVIORAL

Moderate to heavy intensity resistance exercise consisting of leg press.

Control group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise.

Moderate to heavy intensity resistance exercise consisting of leg press.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Primary osteoarthritis of the knee scheduled for knee replacement surgery
* Must be able to perform physical exercise
* Age 40-90 years old
* BMI 18.5-40 kg/m\^2
* None smoker for the last 6 weeks

Exclusion Criteria

* Regular intake of:
* non steroid anti-inflammatory drugs (NSAID)
* corticoid-steroids
* disease modifying anti-rheumatic drugs (DMARD)
* cytostatic incl. chemotherapy
* immune suppressive medicine
* Inflammatory diseases or cancer
* Recent trauma to the knee (\< 3 months)
* Previous knee surgery
* Regular strenuous exercise ( \> 1 pr. month)
* Previous exposure to tracers (e.g. from another study)

Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No