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Osteoarthritis: Weakness From Inflammation

NCT ID: NCT00104312

Last Updated: 2009-05-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

88 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-04-30

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Detailed Description

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Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Conditions

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Osteoarthritis

Keywords

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Knee Osteoarthritis Muscle Cytokine Mobility Function

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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1

Participants with symptomatic knee osteoarthritis

No interventions assigned to this group

2

Participants without symptomatic knee osteoarthritis, age-matched as controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 50 years of age or older
* Normal body weight (a Body Mass Index (BMI) of 30 or less)
* Osteoarthritis of the knee (prior to knee surgery)
* Planning to have knee surgery at a MedStar Hospital

Exclusion Criteria

* History of a stroke
* History of muscle weakness or paralysis
* History of Rheumatoid Arthritis or
* Inflammatory Joint Disease
* History of a Bleeding Disorder
* History of Gout
* Diabetes for which you take insulin
* Polymyalgia rheumatica (total body muscle aching/stiffness)
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role lead

Responsible Party

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National Institute on Aging

Principal Investigators

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Shari Ling, MD

Role: PRINCIPAL_INVESTIGATOR

NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics

Locations

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Harbor Hospital

Baltimore, Maryland, United States

Site Status

Countries

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United States

References

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Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA. Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000 May;43(5):995-1000. doi: 10.1002/1529-0131(200005)43:53.0.CO;2-1.

Reference Type BACKGROUND
PMID: 10817551 (View on PubMed)

Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998 Nov;41(11):1951-9. doi: 10.1002/1529-0131(199811)41:113.0.CO;2-9.

Reference Type BACKGROUND
PMID: 9811049 (View on PubMed)

Conwit RA, Stashuk D, Tracy B, McHugh M, Brown WF, Metter EJ. The relationship of motor unit size, firing rate and force. Clin Neurophysiol. 1999 Jul;110(7):1270-5. doi: 10.1016/s1388-2457(99)00054-1.

Reference Type BACKGROUND
PMID: 10423192 (View on PubMed)

Other Identifiers

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AG0016

Identifier Type: -

Identifier Source: org_study_id