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The Relationship Between Physical Activity and Radiographic Osteoarthritis Worsening

NCT ID: NCT03358641

Last Updated: 2017-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2020-12-31

Brief Summary

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Wuchuan Osteoarthritis Study is a population-based longitudinal study of natural history of knee osteoarthritis and its risk factors. At baseline and follow-up visits, IPA-Q questionnaire and a radiographs at tibiofemoral (TF) joints will be taken in order to assess the relationship between physical activity and radiographic osteoarthritis worsening.

Detailed Description

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1025 residents aged ≥ 50 years will be recruited using door-to-door enumeration in randomly selected rural communities in Wuchuan, China, and will be followed in 3 years. At baseline and follow-up visits, subjects will complete a home interview (including, but not limited to, socio-demographic factors, physical activity level using IPA-Q questionnaire,WOMAC questionnaire) and have a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints. Radiographic osteoarthritis (ROA) worsening for a knee is defined if its Kellgren and Lawrence (K/L) grade increases by at least 1 grade except for the change from 0 to 1 during follow-up. The relationship between level of physical activity and ROA worsening will be assessed.

Conditions

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Osteoarthritis, Knee

Keywords

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exercise physical activity radiographic osteoarthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Wuchuan residents

All residents that meet the criteria can be enrolled in this group, receiving a home interview (including IPA-Q to assess the level of physical activity) and a weight-bearing posteroanterior semiflexed view of radiographs at tibiofemoral (TF) joints at baseline and 3 years later.

level of physical activity

Intervention Type OTHER

According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.

Interventions

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level of physical activity

According to the result of IPA-Q questionnaire, participants are divided in three groups: low level, moderate level, high level of physical activity.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. people aged 50 or over
2. Wuchuan permanent resident population

Exclusion Criteria

1. patients with rheumatoid arthritis
2. the disabled
3. patients with mental disorders
4. laid up for malignant tumor
5. people who live or work outside for more than half a year
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lin Chutong

arthritis clinic and research center

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jianhao Lin, MD

Role: PRINCIPAL_INVESTIGATOR

arthritis clinic and research center

Central Contacts

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Chutong Lin

Role: CONTACT

Phone: +86 15652930253

Email: [email protected]

Other Identifiers

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PKUPHOSM

Identifier Type: -

Identifier Source: org_study_id