Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

NCT ID: NCT06054360

Last Updated: 2023-10-02

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 334 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-04-17
• Study Completion Date: 2025-11-30

Brief Summary

The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute myocardial infarction, and death. While the role of the left atrium (LAF) in the pathophysiology of POAF is now well-established, the part of the right atrium (RA) remains poorly understood. Recent studies suggest a correlation between RA function and POAF.

RA function can be assessed by transthoracic echocardiography (TTE) with dedicated software for measuring the RA strain (RAS). RA function is thus divided into three phases: reservoir (RASr), conduit, and contraction. Numerous studies have demonstrated that a significant alteration in RAS predicts POAF in various clinical contexts. Therefore, it is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

It is essential to investigate whether alterations in RA function assessed by 2D-STE (RAS) are associated with an increased occurrence of FAPO after cardiac surgery.

Conditions

Postoperative Atrial Fibrillation; Strains

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adult patient (>18 years old)
• The patient was hospitalized at the Amiens University Hospital for scheduled aortocoronary bypass grafting under cardiopulmonary bypass.
• Echocardiographic image quality enabling the measurement of RAS parameters
• Patient affiliation to a social security scheme
• Patient/proxy information and collection of their non-opposition.

Exclusion Criteria

• Patients participating in an interventional study may modify the incidence of POAF.
• History of atrial fibrillation or flutter.
• Valvular and ascending aorta cardiac surgery
• Urgent cardiac surgery.
• Presence of tricuspid insufficiency greater than grade 2.
• Left ventricular ejection fraction lower than 50%.
• Patient receiving circulatory mechanical assistance before surgery.
• Dependency on ventricular and atrial pacing by an internal or external cardiac pacemaker during the echocardiographic examination.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU Amiens Picardie

Amiens, , France

Site Status: RECRUITING

Countries

France

Central Contacts

Camille DAUMIN, MD

Role: CONTACT

daumin.camille@chu-amiens.fr

03 22 08 77 95

Facility Contacts

Camille DAUMIN, MD

Role: primary

daumin.camille@chu-amiens.fr

03 22 08 77 95

Other Identifiers

PI2023_843_0048

Identifier Type: -

Identifier Source: org_study_id