Postoperative Atrial Fibrillation in Cardiac Surgery

NCT ID: NCT06958029

Last Updated: 2025-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

275 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-04-01

Study Completion Date

2025-06-10

Brief Summary

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This multicenter observational study aims to investigate the incidence and identify risk factors associated with postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery at three medical centers in Thailand. The study will examine patient characteristics, surgical factors, and anesthetic management practices that may contribute to the development of this common postoperative complication.

Detailed Description

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Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery, with incidence rates reported between 15-30% after valve surgery and 18-74% after coronary artery bypass grafting. POAF typically occurs within 72 hours after surgery and is associated with increased morbidity, mortality, length of hospital stay, and healthcare costs.

The Society of Thoracic Surgeons has identified five major postoperative complications associated with cardiac surgery, including POAF, which can significantly affect patient outcomes. This multicenter observational study will examine the incidence and risk factors of POAF in cardiac surgery patients across three medical centers in Thailand: Srinagarind Hospital at Khon Kaen University, Northeastern Thailand Cardiac Center, and Surat Thani Hospital.

The study will collect data on patient demographics, comorbidities, preoperative laboratory values, perioperative characteristics, surgical procedures (valve surgery, CABG, combined procedures), and postoperative complications. By identifying risk factors associated with POAF, this study aims to develop preventive strategies and improve management protocols for patients at high risk for this complication.

Conditions

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Post-operative Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Cardiac surgery

Patients undergoing cardiac surgery

Cardiac surgery

Intervention Type PROCEDURE

Patients receiving general anesthesia for cardiac surgery

Interventions

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Cardiac surgery

Patients receiving general anesthesia for cardiac surgery

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Patients undergoing cardiac valve surgery or coronary artery bypass grafting (CABG) procedures

Exclusion Criteria

* Patients undergoing aortic surgery
* Patients undergoing MAZE procedure
* Incomplete medical records
* Patients who required mechanical circulatory support before surgery
* Patients who died during surgery or within 3 days after surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Khon Kaen University

OTHER

Sponsor Role lead

Responsible Party

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Thepakorn Sathitkarnmanee

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Thepakorn Sathitkarnmanee, MD

Role: PRINCIPAL_INVESTIGATOR

Khon Kaen University

Locations

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Faculty of Medicine, Khon Kaen University

Khon Kaen, , Thailand

Site Status RECRUITING

Countries

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Thailand

Central Contacts

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Sirirat Tribuddharat, MD, PhD

Role: CONTACT

66-81-6205921

Facility Contacts

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Thepakorn Sathitkarnmanee, MD

Role: primary

+66819547622

References

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Crawford TC, Magruder JT, Grimm JC, Suarez-Pierre A, Sciortino CM, Mandal K, Zehr KJ, Conte JV, Higgins RS, Cameron DE, Whitman GJ. Complications After Cardiac Operations: All Are Not Created Equal. Ann Thorac Surg. 2017 Jan;103(1):32-40. doi: 10.1016/j.athoracsur.2016.10.022. Epub 2016 Nov 22.

Reference Type RESULT
PMID: 27884410 (View on PubMed)

Echahidi N, Pibarot P, O'Hara G, Mathieu P. Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J Am Coll Cardiol. 2008 Feb 26;51(8):793-801. doi: 10.1016/j.jacc.2007.10.043.

Reference Type RESULT
PMID: 18294562 (View on PubMed)

Gudbjartsson T, Helgadottir S, Sigurdsson MI, Taha A, Jeppsson A, Christensen TD, Riber LPS. New-onset postoperative atrial fibrillation after heart surgery. Acta Anaesthesiol Scand. 2020 Feb;64(2):145-155. doi: 10.1111/aas.13507. Epub 2019 Dec 2.

Reference Type RESULT
PMID: 31724159 (View on PubMed)

Melduni RM, Koshino Y, Shen WK. Management of arrhythmias in the perioperative setting. Clin Geriatr Med. 2012 Nov;28(4):729-43. doi: 10.1016/j.cger.2012.08.006.

Reference Type RESULT
PMID: 23101581 (View on PubMed)

Lopes LA, Agrawal DK. Post-Operative Atrial Fibrillation: Current Treatments and Etiologies for a Persistent Surgical Complication. J Surg Res (Houst). 2022;5(1):159-172. doi: 10.26502/jsr.10020209. Epub 2022 Mar 28.

Reference Type RESULT
PMID: 35445200 (View on PubMed)

Other Identifiers

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Khon Kaen University

Identifier Type: OTHER

Identifier Source: secondary_id

HE671492

Identifier Type: -

Identifier Source: org_study_id

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