COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion
NCT ID: NCT06054126
Last Updated: 2023-10-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
2000 participants
OBSERVATIONAL
2010-01-01
2026-03-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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T2DM with good CCC
T2DM was diagnosed according to the criteria of the American Diabetes Association. The diagnosis of CTO was made if at least one lesion was angiographic 100% occlusion. Coronary collateral circulation development was graded according to the Cohen-Rentrop method, grade 2 (partial filling of the epicardial segment by collateral vessels); grade 3 (complete filling of the epicardial artery by collateral vessels) were defined as good coronary collateral circulation.
Echocardiography
Cardiac function was evaluated by echocardiography at one year follow-up.
T2DM with poor CCC
T2DM was diagnosed according to the criteria of the American Diabetes Association. The diagnosis of CTO was made if at least one lesion was angiographic 100% occlusion. Coronary collateral circulation development was graded according to the Cohen-Rentrop method, grade 0 (no filling of any collateral vessels) and grade 1 (filling of side branches of the artery to be perfused by collateral vessels without visualization of the epicardial segment) were defined as poor coronary collateral circulation.
Echocardiography
Cardiac function was evaluated by echocardiography at one year follow-up.
Interventions
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Echocardiography
Cardiac function was evaluated by echocardiography at one year follow-up.
Eligibility Criteria
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Inclusion Criteria
* Type 2 diabetes diagnosed by one of the following criteria:
HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents.
* At least one lesion with angiographic total occlusion
Exclusion Criteria
* chronic heart failure with NYHA grade ≥3
* had a history of coronary artery bypass grafting
* had received a percutaneous coronary intervention within the prior 3 months
* Malignant tumor or immune system disorders
* Pulmonary heart disease
18 Years
90 Years
ALL
No
Sponsors
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Ruijin Hospital
OTHER
Responsible Party
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Locations
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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Countries
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Central Contacts
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Facility Contacts
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References
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Mao LS, Geng L, Wang YX, Qi Y, Wang MH, Ding FH, Dai Y, Lu L, Zhang Q, Shen WF, Shen Y. Clinical risk score to predict poor coronary collateralization in type 2 diabetic patients with chronic total occlusion. BMC Cardiovasc Disord. 2025 Apr 2;25(1):250. doi: 10.1186/s12872-025-04687-8.
Other Identifiers
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sy11218
Identifier Type: -
Identifier Source: org_study_id
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