Dynamic Respiratory Muscle Strength and Endurance in Childhood Asthma

NCT ID: NCT06053905

Last Updated: 2024-08-09

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 40 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-03-13
• Study Completion Date: 2024-03-10

Brief Summary

Peak inspiratory flow (PIF) may be due to respiratory muscle strength, especially in those with severe airflow obstruction. PIF appears to be lower in children and adolescents with asthma than in non-asthmatics and correlates positively with age, height, weight, and respiratory muscle strength. Although physical activity and fitness are also believed to be important in lung health, the relationship between lung function and physical fitness is unclear. It measures dynamic lung volumes, s-index and PIF and provides information on dynamic lung function in children and adolescents. In this study, the dynamic components of the lung will be compared between asthmatic and healthy children, and the relationship between respiratory parameters and physical assessment, such as physical fitness, activity and functional capacity, will be investigated in children with asthma.

Detailed Description

Asthma prevalence is high in childhood and adolescence and the disease imposes an economic burden. In studies, patients with peak inspiratory flow (PIF) showed variability in severe obstruction and a dependence on respiratory muscle strength. PIF appears to be lower in children and adolescents with asthma than in those without asthma and correlates positively with age, height, weight and respiratory muscle strength. Also, although physical activity and fitness are believed to be important in lung health, the relationship between lung function and physical fitness is unclear. Physical activity improves exercise capacity and outcomes in patients with asthma or chronic obstructive pulmonary disease, but there is insufficient evidence that it improves lung function. Physical fitness in childhood and adolescence has been associated with increases in lung volumes throughout early adulthood. These relationships may weaken with age and may not be significant in older age groups. s-Index (a special calculation) and PIF describe dynamic lung volumes. There are very few studies in the literature that dynamically evaluate respiratory muscles and functions compared to their healthy counterparts and interpret these tests together with physical evaluations. In addition, reference values for the s-index and PIF in children with asthma are uncertain due to the small number of studies. The results of this study will contribute to future studies in determining the test reference values.The investigators think that the results of the study will contribute to future studies in determining the test reference values.

Conditions

Asthma in Children

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Asthmatic Child

Children with asthma between 6-11 years old

No interventions assigned to this group

Healthy Controls Group

Healthy children between 6-11 years old

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Hacettepe University Faculty of Medicine, Department of Pediatrics, Allergy and Asthma Unit patients referred for Cardiopulmonary Rehabilitation,
• Those who have been diagnosed with asthma,
• Clinically stable and not in active asthma attack,
• Between the ages of 6-11,
• Giving consent on a voluntary basis,
• cooperative,

• Not having any chronic disease for healthy individuals,
• be between the ages of 6-11,
• Volunteering to participate in the study,
• Not having speech and hearing problems,
• Being cooperative,
• Not having a mental, neurological, orthopedic, cardiovascular or pulmonary problem that would prevent physical activity,

Exclusion Criteria

• Those whose clinical status is not stable and who are in active asthma attack,
• Having serious diseases such as cancers, heart failure and acute respiratory infections,
• Having chronic lung disease other than asthma,
• Severe neuromuscular and musculoskeletal problems,
• Uncooperative to do the tests,
• For safety reasons, patients admitted or hospitalized in the last 3 months due to an asthma attack will not be included in the study.

• The presence of a medical indication that requires complete restriction of physical activity,
• Having symptoms of any chronic or acute illness involving the lungs
• Existence of cooperation and communication problems

• Minimum Eligible Age: 6 Years
• Maximum Eligible Age: 11 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hacettepe University

OTHER

Sponsor Role: collaborator

Bartın Unıversity

OTHER

Sponsor Role: lead

Responsible Party

Şeyma Nur Önal

Lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ebru Calik Kutukcu, PhD

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

Locations

Ebru Çalik Kütükcü

Ankara, Altındağ, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

GO23/241

Identifier Type: -

Identifier Source: org_study_id