Respiratory and Hemodynamic Targets During General Anesthesia
NCT ID: NCT06047119
Last Updated: 2025-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
485 participants
INTERVENTIONAL
2023-10-09
2025-04-24
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
DOUBLE
Study Groups
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Mean arterial blood pressure above 60 mmHg during general anesthesia and 2 hours after
Blood pressure
Blood pressure targets during general anesthesia and 2 hours after
Mean arterial blood pressure above 70 mmHg during general anesthesia and 2 hours after
Blood pressure
Blood pressure targets during general anesthesia and 2 hours after
Mean arterial blood pressure above 80 mmHg during general anesthesia and 2 hours after
Blood pressure
Blood pressure targets during general anesthesia and 2 hours after
Systolic blood pressure above 90% of baseline during general anesthesia and 2 hours after
Blood pressure
Blood pressure targets during general anesthesia and 2 hours after
Positive end expiratory pressure 5 cm H20 during general anesthesia
Positive end expiratory pressure
Positive end expiratory pressure during general anesthesia
Positive end expiratory pressure 8 cm H20 during general anesthesia
Positive end expiratory pressure
Positive end expiratory pressure during general anesthesia
Positive end expiratory pressure 10 cm H20 during general anesthesia
Positive end expiratory pressure
Positive end expiratory pressure during general anesthesia
Tidal volume 5 ml/kg during general anesthesia
Tidal volume
Tidal volume during general anesthesia
Tidal volume 8 ml/kg during general anesthesia
Tidal volume
Tidal volume during general anesthesia
Tidal volume 10 ml/kg during general anesthesia
Tidal volume
Tidal volume during general anesthesia
Fraction of inspired oxygen 30% during general anesthesia and 2 hours after
Fraction of inspired oxygen
Fraction of inspired oxygen during general anesthesia and 2 hours after
Fraction of inspired oxygen 80% during general anesthesia and 2 hours after
Fraction of inspired oxygen
Fraction of inspired oxygen during general anesthesia and 2 hours after
Interventions
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Blood pressure
Blood pressure targets during general anesthesia and 2 hours after
Positive end expiratory pressure
Positive end expiratory pressure during general anesthesia
Tidal volume
Tidal volume during general anesthesia
Fraction of inspired oxygen
Fraction of inspired oxygen during general anesthesia and 2 hours after
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) classification 3 to 5
* Planned endotracheal intubation with positive pressure ventilation
* Expected operating time ≥ 90 minutes
* Certain types of surgery
Exclusion Criteria
* Known or suspected pregnancy
* Out-patient/same-day surgery
* Intubated prior to surgery
* Clinical judgement by the anesthesiologist that any of the interventions could be potentially harmful to the patient
18 Years
ALL
No
Sponsors
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Lars Wiuff Andersen
OTHER
Responsible Party
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Lars Wiuff Andersen
Associate Professor
Locations
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Aalborg University Hospital
Aalborg, , Denmark
Aarhus University Hospital
Aarhus, , Denmark
Gødstrup Regional Hospital
Gødstrup, , Denmark
Horsens Regional Hospital
Horsens, , Denmark
Randers Regional Hospital
Randers, , Denmark
Viborg Regional Hospital
Viborg, , Denmark
Countries
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References
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Hoybye M, Lind PC, Holmberg MJ, Bolther M, Jessen MK, Vallentin MF, Hansen FB, Holst JM, Magnussen A, Hansen NS, Johannsen CM, Enevoldsen J, Jensen TH, Roessler LL, Klitholm MP, Eggertsen MA, Caap P, Boye C, Dabrowski KM, Vormfenne L, Henriksen J, Karlsson M, Balleby IR, Rasmussen MS, Paelestik K, Granfeldt A, Andersen LW. Fraction of inspired oxygen during general anesthesia for non-cardiac surgery: Systematic review and meta-analysis. Acta Anaesthesiol Scand. 2022 Sep;66(8):923-933. doi: 10.1111/aas.14102. Epub 2022 Jun 23.
Bolther M, Henriksen J, Holmberg MJ, Jessen MK, Vallentin MF, Hansen FB, Holst JM, Magnussen A, Hansen NS, Johannsen CM, Enevoldsen J, Jensen TH, Roessler LL, Caroe Lind P, Klitholm MP, Eggertsen MA, Caap P, Boye C, Dabrowski KM, Vormfenne L, Hoybye M, Karlsson M, Balleby IR, Rasmussen MS, Paelestik K, Granfeldt A, Andersen LW. Ventilation Strategies During General Anesthesia for Noncardiac Surgery: A Systematic Review and Meta-Analysis. Anesth Analg. 2022 Nov 1;135(5):971-985. doi: 10.1213/ANE.0000000000006106. Epub 2022 Oct 21.
Bolther M, Henriksen J, Holmberg MJ, Granfeldt A, Andersen LW. Blood pressure targets during general anaesthesia for noncardiac surgery: A systematic review of clinical trials. Eur J Anaesthesiol. 2022 Nov 1;39(11):903-905. doi: 10.1097/EJA.0000000000001703. Epub 2022 Jul 5. No abstract available.
Holst JM, Klitholm MP, Henriksen J, Vallentin MF, Jessen MK, Bolther M, Holmberg MJ, Hoybye M, Lind PC, Granfeldt A, Andersen LW. Intraoperative respiratory and hemodynamic strategies for reducing nausea, vomiting, and pain after surgery: Systematic review and meta-analysis. Acta Anaesthesiol Scand. 2022 Oct;66(9):1051-1060. doi: 10.1111/aas.14127. Epub 2022 Aug 22.
Other Identifiers
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00005
Identifier Type: -
Identifier Source: org_study_id
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