Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

NCT ID: NCT06025903

Last Updated: 2024-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-20

Study Completion Date

2025-05-30

Brief Summary

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The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.

Detailed Description

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Multiple Sclerosis is a major cause of neurological disability, with a high socio-economic impact that increases as disability progresses. Effective treatment of primary progressive multiple sclerosis is still an unmet need and the underlying neurodegenerative processes have to be fully investigated. The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Altered mitochondrial pathways will be investigate, as well as inherited and tissue-specific somatic mitochondrial variations associated with primary progressive multiple sclerosis.

Conditions

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Multiple Sclerosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Primary Progressive multiple sclerosis

patients affected by primary progressive multiple sclerosis

No interventions assigned to this group

Relapsing Remitting multiple sclerosis

patients affected by primary progressive multiple sclerosis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients affected by primary progressive or relapsing remitting multiple sclerosis
* Patient able to provide informed consent

Exclusion Criteria

* Individuals with \< 18 years
* Patients not affected by primary progressive or relapsing remitting multiple sclerosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Azienda Socio Sanitaria Territoriale della Valle Olona

OTHER

Sponsor Role collaborator

IRCCS San Raffaele

OTHER

Sponsor Role lead

Responsible Party

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Melissa Sorosina

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Melissa Sorosina

Role: PRINCIPAL_INVESTIGATOR

IRCCS San Raffaele

Locations

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IRCCS San Raffaele

Milan, MI, Italy

Site Status RECRUITING

ASST della Valle Olona - Ospedale di Gallarate

Gallarate, VA, Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Federica Esposito

Role: CONTACT

0226437833

Facility Contacts

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Federica Esposito

Role: primary

Clara Guaschino

Role: primary

Other Identifiers

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MitoMS_GR-2019-12368672

Identifier Type: -

Identifier Source: org_study_id

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