Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-06

Study Completion Date

2026-02-05

Brief Summary

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This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.

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Detailed Description

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The heterogeneity of multiple sclerosis evolution relies on several pathophysiological mechanisms including neuroinflammation, neurodegeneration and remyelination and repair mechanisms.

The study will identify markers of disease severity in a longitudinal cohort of patients with multiple sclerosis who are siblings (both siblings having multiple sclerosis) including: biological markers (genetic, immunological and epigenetic markers, advanced MRI markers). An integrative model to predict disease progression will be proposed based on multimodal markers.

Conditions

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Multiple Sclerosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Multiple Sclerosis siblings

Group of siblings having multiple sclerosis, n=120 Composite severity score calculation for all subjects

Composite severity score calculation

Intervention Type OTHER

Neurological examination, cognitive testing, and MRI exam

Interventions

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Composite severity score calculation

Neurological examination, cognitive testing, and MRI exam

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria)
* Sibling having Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria) willing to participate to the study
* Affiliated to the French social security or equivalent

Exclusion Criteria

* Cyclophosphamide, mitoxantrone or methylprednisolone infusion within one month before inclusion
* Multiple sclerosis relapse within one month before inclusion
* Concomitant severe or uncontrolled disease

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No