Registry Study in MSI/dMMR Solid Tumors

NCT ID: NCT06004713

Last Updated: 2023-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

190 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-07

Study Completion Date

2026-02-28

Brief Summary

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This study is a multi-center, non-interventional, prospective clinical observational study, aiming to evaluate the effectiveness and safety of subsequent treatment in dMMR/MSI solid tumor patients who have never received ICIs under real-world conditions. Particular attention is paid to the efficacy in populations where treatment plans are adjusted based on ctDNA, and potential predictive or prognostic biomarkers are explored.

Detailed Description

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This study plans to enroll patients in the following four cohorts:

* Cohort A: Initially only receiving PD1/PDL1 monotherapy;
* Cohort B: Initially receiving simultaneous blockade of PD1/PDL1 and CTLA4;
* Cohort C: Initially receiving PD1/PDL1 monotherapy combined with chemotherapy or targeted therapy;
* Cohort D: Initially not using ICIs, receiving other standard treatments for this tumor type

To explore the role of ctDNA testing in therapeutic decision-making, patients with the first evaluation of SD in cohort A are divided into two groups: ctDNA testing/intervention group (Group A1) and ctDNA testing/non-intervention group (Group A2). In group A1, if there is no early response to ctDNA, the researchers and the patient will decide to add CTLA4 antibody or other potentially effective treatments after thorough communication. If there is an early response to ctDNA, then continue with PD1/PDL1 monoclonal antibody treatment. Patients in group A2 undergo ctDNA testing, but still continue with PD1/PDL1 monoclonal antibody treatment according to the RECIST v1.1 standard when the first evaluation of SD is made. Meanwhile, explore the role of 1-year ctDNA-MRD in guiding treatment in patients with long-term tumor control, and explore the guiding role of re-biopsy of tumor tissue or ctDNA testing in helping making treatment regimen after progression on ICIs.

Number of Subjects:

• This study will recruit patients nationwide for data collection over a period of 3 years. The plan is to enroll 100 cases in Cohort A, including 25 cases in Group A1 and 25 cases in Group A2; 30 cases in Cohort B; 30 cases in Cohort C; and 30 cases in Cohort D.

Conditions

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DMMR Cancer MSI-H Solid Tumor

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort A

Patients will initially receive monotherapy PD1/PDL1 monoclonal antibody therapy.

No interventions assigned to this group

Cohort B

Patients will initially receive dual blockade of both PD1/PDL1 and CTLA4

No interventions assigned to this group

Cohort C

Patients will initially receive PD1/PDL1 monoclonal antibody combined with chemotherapy or targeted therapy.

No interventions assigned to this group

Cohort D

Patients will receive other standard treatments for this tumor other than ICIs.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Sign the informed consent form and voluntarily participate in this study;
* Age ≥ 18 years old; age should also be ≤75 years old in Cohorts B, C, D;
* Histologically or cytologically confirmed to have a solid malignant tumor and confirmed by immunohistochemistry to be dMMR or confirmed by PCR/NGS to be MSI;
* The researcher determines that the patient can receive anti-tumor treatment;
* Have evaluable lesions

Exclusion Criteria

* Other malignant tumors within 5 years before joining the study, except for cured skin squamous cell carcinoma, basal cell carcinoma, non-muscle invasive bladder cancer, localized low-risk prostate cancer (defined as stage ≤T2a, Gleason score ≤6 points, and prostate cancer diagnosed with PSA ≤10 ng/mL (if measured). Patients who have received radical treatment and have no prostate specific antigen (PSA) biochemical recurrence can participate in this study), cervical/breast carcinoma in situ, and Lynch syndrome;
* Evidence already exists that the patient is a pregnant or lactating woman;
* Previous treatment with immune checkpoint inhibitors or T cell co-stimulatory drugs, including but not limited to PD1, CTLA4, LAG3, and other immune checkpoint blockers, therapeutic vaccines, etc.; patients exposed to ICIs in perioperative setting are allowed to be enrolled if disease relapse after more than 6 months since the last dose of ICIs;
* Other situations deemed by the researcher to be unsuitable for inclusion in the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University Cancer Hospital & Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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zhenghang Wang

Role: STUDY_DIRECTOR

Peking University Cancer Hospital & Institute

Locations

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Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute

Beijin, Beijing Municipality, China

Site Status RECRUITING

Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Site Status RECRUITING

Department of Oncology, The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

Site Status RECRUITING

Medical Oncology Department of Gastrointestinal Cancer, Liaoning Cancer Hospital & Institute

Shengyang, Liaoning, China

Site Status RECRUITING

Department of Oncology, The Affiliated Hospital of Qingdao University

Qingdao, Shandong, China

Site Status RECRUITING

Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital

Taiyuan, Shanxi, China

Site Status RECRUITING

Department of Medical Oncology, Peking University First Hospital

Beijing, , China

Site Status RECRUITING

Department of Oncology, Beijing Luhe Hospital Affiliated to Capital Medical University

Beijing, , China

Site Status RECRUITING

Department of Oncology, Peking University Shougang Hospital

Beijing, , China

Site Status RECRUITING

Department of Gastrointestinal Oncology, Tianjin Medical University Cancer Institute and Hospital

Tianjin, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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zhenghang Wang

Role: CONTACT

18813186790

Facility Contacts

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Zhenghang Wang

Role: primary

Fengbin Zhang

Role: primary

Zhiwei Chang

Role: primary

Qiwei Wang

Role: primary

Zimin Liu

Role: primary

Hongxia Lu

Role: primary

Xuan Jin

Role: primary

Dong Yan

Role: primary

Xiaodong Wang

Role: primary

Ting Deng

Role: primary

References

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Other Identifiers

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LGH2023093

Identifier Type: -

Identifier Source: org_study_id

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