Neuromuscular Blockade Monitoring Using Kine-myography vs Electromyography.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

129 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-10

Study Completion Date

2024-05-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study aims to compare two monitoring methods of neuromuscular blockade - Kine-myography and Electromyography.

The main questions to answer are:

* are electromyography and kine-myography interchangeable
* is electromyography linked to fewer fault results
* is electromyography using lower energy to stimulate nerves

The type of study is a multicentric observational clinical trial. Subjects are patients undergoing general anaesthesia with the use of rocuronium or cis-atracurium. In each patient, the neuromuscular blockade will be monitored using kine-myograph and electromyography simultaneously.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Improving Neuromuscular Monitoring and Reducing Residual Neuromuscular Blockade Via E-learning

NCT02925143

Neuromuscular Blockade

COMPLETED NA

Development and Validation of an Android-based Application for Anaesthesia Neuromuscular Monitoring

NCT03605225

Neuromuscular Blockade Neuromuscular Monitoring

COMPLETED NA

Neuromuscular Monitoring:TOFCuff Versus EMG

NCT04282213

Neuromuscular Blockade

COMPLETED

OS NMB Depth Measured by Central and Peripheral Monitor.

NCT03660891

Neuromuscular Blockade

UNKNOWN

Comparison of Three Methods of Anesthesia to Achieve a Nerve Block Anesthesia.

NCT05345665

Anesthesia

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Informed consent will first be obtained from the patient for inclusion in the study. Consent will be obtained during an examination by the anaesthesiologist providing anaesthetic care during surgery in the anteroom of the operating theatre.

Once informed consent has been obtained, a routine orientation examination will be performed by the anaesthetist and routine pre-operative preparation (provision of peripheral venous access, risk assessment for airway obstruction, etc.) will be performed. The patient will then be transported to the operating theatre.

In the operating room, patient monitoring will be initiated, including the deployment of sensors to monitor the depth of neuromuscular blockade. The KMG sensor will be placed on the right arm and the EMG sensor on the left arm. After deployment of the sensors, upper limb fixation will be performed by the anaesthetic nurse. The fixation will be performed with splints compatible with the operating table. Fixation of the limbs and sensor with adhesive tape will not be used.

The anaesthesia will then be induced. Propofol and sufentanil will be administered at the discretion of the anaesthetist providing anaesthetic care. Once sufficient depth of sedation has been induced, calibration of the sensors monitoring the depth of neuromuscular blockade will be performed. After calibration of the sensors, the supramaximal current to the CRF will be recorded. The measurement interval will be set to 20 s. After securing the airway, the interval will be extended to 5 - 15 min according to the nature of the surgery and the discretion of the anaesthesiologist providing anaesthetic care. The number of twitches (PCT) and the Train Of Four (TOF) value will be recorded throughout the procedure.

On emergence from anaesthesia, the measurement interval will be set to 1 minute. Once sufficient depth of neuromuscular blockade has been reached to allow extubation, monitoring of the depth of neuromuscular blockade will be discontinued.

If during the measurement of the depth of neuromuscular blockade a value is measured that is highly suspected to be in error, this suspicion will be recorded in the CRF with a justification.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neuromuscular Blockade Residual Neuromuscular Blockade

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* patients undergoing surgery under general anaesthesia with the use of cis-atracurium or rocuronium

Exclusion Criteria

* patients suffering from neuromuscular diseases
* patients with known allergy to rocuronium or cis-atracurium
* patients in whom it is impossible to measure the depth of the neuromuscular block on the upper extremities (injuries of the upper extremities, contractures etc.)
* patients undergoing surgery positioned on their side
* patients with an upper arm injury
* patients with acromegaly
* patients with Alzheimer's disease
* patients with the risk of difficult airways
* patients induced into general anaesthesia via the Rapid Sequence Induction method
* patients with a weight under 5 kilograms

Eligible Sex

ALL

Accepts Healthy Volunteers

No