Postoperative Residual Curarization in 2018

NCT ID: NCT03665805

Last Updated: 2018-11-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 587 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-07-30
• Study Completion Date: 2018-11-12

Brief Summary

The primary objective of this study is to evaluate the incidence of postoperative residual curarization, as defined by a train-of-four <90%, upon postanaesthesia care unit arrival. Anesthetists tend to use train-of-four monitoring in the operating theatre to interpret muscle tone. Train-of-four monitoring is a widely used term for the peripheral nerve stimulation used in neuromuscular blockade monitoring. Hypothesizing a change in our practice since 2006-2012 (Cammu G, Anesth Analg 2006; 102: 426-9 and Cammu G, Anaesth Intensive Care 2012; 40: 999-1006), residual neuromuscular block as well as the use of intraoperative neuromuscular transmission monitoring and reversal of neuromuscular blocking agents will again be prospectively evaluated in 2018. The present study aims to compare these three periods (2006-2012-2018) in terms of management of neuromuscular block in the operating room and to look for a relationship with the incidence of postoperative residual curarization.

Conditions

Postoperative Residual Curarization

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

neuromuscular transmission monitoring

The acceleromyographic responses of the adductor pollicis muscle as percent of the train-of-four (TOF%) on stimulation of the ulnar nerve by means of the TOFscan neuromuscular transmission monitor (iDMed, Marseille, France).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 18 years of age or older;
• Informed consent signed;
• Admission for elective surgery;
• Administration of non-depolarizing neuromuscular blocking agents during surgery;
• Tracheal intubation

Exclusion Criteria

• Evidence of renal, hepatic, metabolic, and/or neuromuscular disorders
• Ejection fraction <20%
• Admission for emergency surgery; or cardiothoracic surgery
• Reoperation during the same hospital admission

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Onze Lieve Vrouw Hospital

OTHER

Sponsor Role: lead

Responsible Party

Guy CAMMU

Staff Anesthesiologist

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

OLV Hospital

Aalst, , Belgium

Countries

Belgium

References

Cammu G, De Witte J, De Veylder J, Byttebier G, Vandeput D, Foubert L, Vandenbroucke G, Deloof T. Postoperative residual paralysis in outpatients versus inpatients. Anesth Analg. 2006 Feb;102(2):426-9. doi: 10.1213/01.ane.0000195543.61123.1f.

Reference Type: BACKGROUND

PMID: 16428537 (View on PubMed)

Cammu GV, Smet V, De Jongh K, Vandeput D. A prospective, observational study comparing postoperative residual curarisation and early adverse respiratory events in patients reversed with neostigmine or sugammadex or after apparent spontaneous recovery. Anaesth Intensive Care. 2012 Nov;40(6):999-1006. doi: 10.1177/0310057X1204000611.

Reference Type: BACKGROUND

PMID: 23194209 (View on PubMed)

Other Identifiers

LKGC2018

Identifier Type: -

Identifier Source: org_study_id