Time Course of a Misperception of Verticality and Its Characteristics in Post-stroke Participants
NCT ID: NCT05978596
Last Updated: 2023-08-07
Study Results
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Basic Information
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UNKNOWN
40 participants
OBSERVATIONAL
2021-10-01
2024-12-31
Brief Summary
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* The time course of verticality perception (Subjective Visual, Haptic and Postural Vertical; resp., SVV, SHV, SPV);
* The longitudinal interaction of the recovery of spatial disorders (e.g., different types of neglect, lateropulsion) with verticality perception;
* The longitudinal interaction of motor function and outcomes (such as paresis, sitting balance and standing balance) and verticality perception.
The participants will be repetitively assessed during the subacute phase post-stroke, to evaluate the time course of:
* The SVV, SHV and SPV;
* Spatial disorders (visuospatial and personal neglect, lateropulsion)
* Motor function (lower limb strength, sitting and standing balance, functionality in ADL, trunk performance)
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Detailed Description
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Different modalities of verticality perception can be assessed, including the Subjective Visual (SVV), Haptic (SHV) and Postural (SPV) Vertical. Previous studies reported a deviation of the subjective vertical in post-stroke patients. These deviations are associated with poorer balance performance. However, some stroke participants have more difficulties with accurately estimating a vertical position as compared to others. This increased magnitude is often seen in participants with lateropulsion or spatial neglect.
Although previous studies showed an increased deviation of the subjective vertical in post-stroke patients, little is known about the recovery of this misperception of verticality. Especially in patients with spatial disorders (e.g., lateropulsion or (different subtypes of) neglect), there is clear lack of studies assessing the longitudinal recovery of a misperception of verticality. Knowledge about the spontaneous recovery of a deviated verticality perception and its association with spatial disorders, will give insights in the role of a misperception of verticality in these disorders.
Although disturbances in perceiving verticality and decreased balance performance seems to be related, it is unclear how these disturbances exactly impacts balance and functional outcome. A longitudinal interaction between verticality perception and motor function will be evaluated.
Participants will be recruited from rehabilitation hospital Revarte (Edegem) or AZ Monica (Antwerp). Participants will be included at 3 or 5 weeks post-stroke and evaluation will take place at 3, 5, 8 and 12 weeks post-stroke. Also, in healthy participants the SVV, SHV and SPV will be evaluated to obtain normative data.
The outcome measures contain:
* Perception of verticality: SVV, SHV, SPV;
* Combination of pen-and-paper tasks and computerized tests to asses visuospatial and personal neglect;
* Clinical scales to evaluate lateropulsion;
* Clinical scales to evaluate motor function (lower limb strength, sitting balance, standing balance, functionality in ADL, trunk performance);
* Instrumented analysis to assess sitting and standing balance.
For the data-analysis Linear Mixed Models will be used, to evaluate study results and mean change over time.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Able to give written informed consent.
Exclusion Criteria
* Vestibular dysfunction, symptomatic orthostatic hypotension or other pre-existing neurological conditions that could interfere with the assessments;
* Inability to understand and follow basic verbal instructions;
* Hemianopsia or other visual field deficits (glasses or corrective lenses are allowed)
And a group of healthy controls to obtain normative data. These participants are eligible for inclusion if they are between 18 and 90 years old and do not suffer from vestibular dysfunction, symptomatic orthostatic hypotension or other neurological conditions that could interfere with the assessment.
18 Years
90 Years
ALL
Yes
Sponsors
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Universiteit Antwerpen
OTHER
Responsible Party
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Wim Saeys
Professor Dr. Wim Saeys
Principal Investigators
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Wim Saeys, Prof. Dr.
Role: PRINCIPAL_INVESTIGATOR
Universiteit Antwerpen
Locations
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AZ Monica
Antwerp, , Belgium
RevArte
Edegem, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Jelena Warmenbol
Role: backup
Wim Saeys, Dr
Role: backup
References
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van der Waal C, Embrechts E, Loureiro-Chaves R, Gebruers N, Truijen S, Saeys W. Lateropulsion with active pushing in stroke patients: its link with lesion location and the perception of verticality. A systematic review. Top Stroke Rehabil. 2023 Apr;30(3):281-297. doi: 10.1080/10749357.2022.2026563. Epub 2022 Feb 1.
Embrechts E, van der Waal C, Anseeuw D, van Buijnderen J, Leroij A, Lafosse C, Nijboer TC, Truijen S, Saeys W. Association between spatial neglect and impaired verticality perception after stroke: A systematic review. Ann Phys Rehabil Med. 2023 Apr;66(3):101700. doi: 10.1016/j.rehab.2022.101700. Epub 2022 Dec 1.
Perennou DA, Mazibrada G, Chauvineau V, Greenwood R, Rothwell J, Gresty MA, Bronstein AM. Lateropulsion, pushing and verticality perception in hemisphere stroke: a causal relationship? Brain. 2008 Sep;131(Pt 9):2401-13. doi: 10.1093/brain/awn170. Epub 2008 Aug 4.
Bonan IV, Leman MC, Legargasson JF, Guichard JP, Yelnik AP. Evolution of subjective visual vertical perturbation after stroke. Neurorehabil Neural Repair. 2006 Dec;20(4):484-91. doi: 10.1177/1545968306289295.
van der Waal C, Saeys W, Truijen S, Embrechts E. Clinical Assessment of Subjective Visual and Haptic Vertical Norms in Healthy Adults. Arch Clin Neuropsychol. 2024 Nov 22;39(8):1408-1417. doi: 10.1093/arclin/acae049.
Other Identifiers
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CvdW
Identifier Type: -
Identifier Source: org_study_id
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