Verticality Perception in Stroke Patients

NCT ID: NCT02184923

Last Updated: 2020-01-07

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 130 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-08-31
• Study Completion Date: 2020-12-31

Brief Summary

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright.The strategy of this research is to quantify changes in verticality perception after unilateral lesions along the central graviceptive pathways and to assess the frequency and pattern of abnormal verticality perception in patients with acute stroke (ischemic or hemorrhagic). Our underlying hypothesis is that screening for erroneous verticality perception by use of a mobile device assessing the subjective visual vertical (SVV) during the acute phase (i.e., within 24-48 hours after symptom onset) reliably identifies those patients with defects. Early detection of deficits in verticality perception may help to initiate balance physiotherapy early.

Conditions

Verticality Perception in Stroke

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

verticality measurements

Group Type: EXPERIMENTAL

presentation of visual vertical

Intervention Type: OTHER

Interventions

presentation of visual vertical

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. ages 18-90 years

2. informed consent

3. for group 1: acute (i.e. symptom onset <3 days ago) lateralized ischemia or hemorrhage as confirmed by clinical examination and / or brain imaging (CT or MRI).

Exclusion Criteria

1. history of a peripheral-vestibular deficit

2. disturbed consciousness

3. severe sensory or motor aphasia

4. visual field deficits

5. other neurological or systemic disorder which can cause dementia or cognitive dysfunction

6. intake of antidepressants, sedatives, or neuroleptics

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Zurich

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Dominik Straumann, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Zurich, Division of Neurology

Locations

University Hospital Zurich

Zurich, Canton of Zurich, Switzerland

Countries

Switzerland

References

Zwergal A, Rettinger N, Frenzel C, Dieterich M, Brandt T, Strupp M. A bucket of static vestibular function. Neurology. 2009 May 12;72(19):1689-92. doi: 10.1212/WNL.0b013e3181a55ecf.

Reference Type: BACKGROUND

PMID: 19433743 (View on PubMed)

Other Identifiers

verticality_percept_stroke_zrh

Identifier Type: -

Identifier Source: org_study_id