Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks
NCT ID: NCT05961800
Last Updated: 2025-07-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
40 participants
INTERVENTIONAL
2023-07-05
2026-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Quantitative Sensory Testing
Participants with chronic low back pain and a scheduled lumbar medial branch block undergo quantitative sensory testing.
Cutaneous Probe
A computer-controlled probe delivers temperatures to the skin to measure pain, offset analgesia and onset hyperalgesia.
Quantitative Sensory Testing
Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain
Computer Tasks
Quantitative Sensory Testing (QST) and computer tasks are used to measure changes in pain intensity.
Interventions
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Cutaneous Probe
A computer-controlled probe delivers temperatures to the skin to measure pain, offset analgesia and onset hyperalgesia.
Quantitative Sensory Testing
Standard methods involving pinprick, pressure, heat, and cold applied to the skin are used to measure sensation and pain
Computer Tasks
Quantitative Sensory Testing (QST) and computer tasks are used to measure changes in pain intensity.
Eligibility Criteria
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Inclusion Criteria
* Age \> 18 years old
* Predominantly axial chronic low back pain at least 3 months on a daily basis
* Must meet the minimum criteria for cognitive function using the PROMIS 2-item cognitive screener (\>3)
* Low back pain intensity of \> 3/10
* Willing and able to receive study-related phone calls
Exclusion Criteria
* Active worker's compensation or litigation claims
* New pain and/or psychiatric treatments within 2 weeks of enrollment
* Not fluent in English and/or not able to complete the questionnaires
* Any clinically unstable systemic illness that is judged to interfere with the study
18 Years
ALL
No
Sponsors
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University of Pittsburgh
OTHER
Responsible Party
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Benedict Alter
Assistant Professor
Principal Investigators
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Benedict J Alter, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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UPMC St. Margaret
Pittsburgh, Pennsylvania, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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STUDY23040122
Identifier Type: -
Identifier Source: org_study_id
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