A Study of Ozanimod in Pregnant Women With Ulcerative Colitis and Their Offspring

NCT ID: NCT05953402

Last Updated: 2025-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

1182 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-12-03

Study Completion Date

2033-06-30

Brief Summary

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The purpose of this study is to evaluate association between ozanimod exposure during pregnancy and subsequent maternal, fetal, and infant outcomes.

Detailed Description

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Conditions

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Ulcerative Colitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Ozanimod-exposed participants with UC

Pregnant women with a diagnosis of UC who are exposed to ozanimod at any time during pregnancy

No interventions assigned to this group

Conventional therapy-exposed participants with UC

Pregnant women with a diagnosis of UC who are exposed to conventional therapies (aminosalicylates and/or thiopurines) but not exposed to ozanimod, other S1P therapies, or advanced therapies for UC (biologics and/or small molecules) at any time during pregnancy

No interventions assigned to this group

Advanced therapy-exposed participants with UC

Pregnant women with a diagnosis of UC who are exposed to advanced therapies for UC (biologics and/or small molecules) but not exposed to ozanimod or other S1P therapies at any time during pregnancy

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Currently or recently pregnant
* Diagnosis of UC
* Resident of country where ozanimod is prescribed for the treatment of UC

Exclusion Criteria

* Exposure to other S1P therapies at any time during pregnancy

Other protocol-defined eligibility criteria apply.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Central Contacts

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BMS Study Connect Contact Center www.BMSStudyConnect.com

Role: CONTACT

855-907-3286

First line of the email MUST contain the NCT# and Site #.

Role: CONTACT

Related Links

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Other Identifiers

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IM047-026

Identifier Type: -

Identifier Source: org_study_id

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