A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

NCT ID: NCT05076175

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

PHASE2/PHASE3

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-30

Study Completion Date

2031-08-14

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be administered orally to pediatric participants with moderate to severe active ulcerative colitis (UC) who have had an inadequate response to conventional therapy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Colitis, Ulcerative

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Ozanimod High Dose

Group Type EXPERIMENTAL

Ozanimod

Intervention Type DRUG

Specified dose on specified days

Ozanimod Low Dose

Group Type EXPERIMENTAL

Ozanimod

Intervention Type DRUG

Specified dose on specified days

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Ozanimod

Specified dose on specified days

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

RPC1063

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Moderately to severely active Ulcerative Colitis (UC) diagnosed prior to the Screening Visit
* Evidence of UC extending beyond the rectum, as determined by baseline endoscopy
* Has had an inadequate response, loss of response to, or is intolerant to at least 1 of the following treatments for UC: oral aminosalicylates, systemic corticosteroids, immunomodulators, biologic therapy

Exclusion Criteria

* Diagnosis of Crohn's disease or indeterminate colitis
* Has documentation of positive test for toxin producing Clostridium difficile, or polymerase chain reaction examination of the stool
* Apheresis within 2 weeks of randomization
* History of or currently active primary or secondary immunodeficiency, or participants with known genetic disorders as a cause for colitis
Minimum Eligible Age

2 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Local Institution - 0041

Phoenix, Arizona, United States

Site Status WITHDRAWN

University of Arizona

Tucson, Arizona, United States

Site Status WITHDRAWN

Local Institution - 0052

Garden Grove, California, United States

Site Status COMPLETED

Loma Linda University Health System

Loma Linda, California, United States

Site Status RECRUITING

Cedars-Sinai Medical Center

Los Angeles, California, United States

Site Status RECRUITING

Lucile Packard Children's Hospital

Palo Alto, California, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0096

Sacramento, California, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0007

Hartford, Connecticut, United States

Site Status COMPLETED

Local Institution - 0064

Washington D.C., District of Columbia, United States

Site Status COMPLETED

Local Institution - 0075

Orlando, Florida, United States

Site Status COMPLETED

Local Institution - 0016

Atlanta, Georgia, United States

Site Status COMPLETED

Local Institution - 0101

Park Ridge, Illinois, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0100

Indianapolis, Indiana, United States

Site Status NOT_YET_RECRUITING

University of Iowa

Iowa City, Iowa, United States

Site Status RECRUITING

Maine Medical Partners

Portland, Maine, United States

Site Status NOT_YET_RECRUITING

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status RECRUITING

Local Institution - 0042

Springfield, Massachusetts, United States

Site Status COMPLETED

University of Massachusetts Chan Medical School

Worcester, Massachusetts, United States

Site Status RECRUITING

Children's Hospital of Michigan

Detroit, Michigan, United States

Site Status RECRUITING

Mayo Clinic in Rochester, Minnesota

Rochester, Minnesota, United States

Site Status RECRUITING

Washington University

St Louis, Missouri, United States

Site Status RECRUITING

Local Institution - 0028

New York, New York, United States

Site Status COMPLETED

Columbia University Medical Center

New York, New York, United States

Site Status RECRUITING

Local Institution - 0023

New York, New York, United States

Site Status WITHDRAWN

University of North Carolina Medical Center

Chapel Hill, North Carolina, United States

Site Status WITHDRAWN

Local Institution - 0047

Charlotte, North Carolina, United States

Site Status COMPLETED

Cleveland Clinic

Cleveland, Ohio, United States

Site Status RECRUITING

Local Institution - 0062

Oklahoma City, Oklahoma, United States

Site Status WITHDRAWN

Penn State Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status RECRUITING

Local Institution - 0099

Charleston, South Carolina, United States

Site Status NOT_YET_RECRUITING

Local Institution - 0103

Fort Worth, Texas, United States

Site Status NOT_YET_RECRUITING

Texas Children's Hospital

Houston, Texas, United States

Site Status RECRUITING

Seattle Children's Hospital

Seattle, Washington, United States

Site Status RECRUITING

Local Institution - 0091

Seattle, Washington, United States

Site Status COMPLETED

MultiCare Health System

Tacoma, Washington, United States

Site Status RECRUITING

Children's Wisconsin

Milwaukee, Wisconsin, United States

Site Status RECRUITING

The Children's Hospital at Westmead

Westmead, New South Wales, Australia

Site Status RECRUITING

Monash Health

Clayton, Victoria, Australia

Site Status RECRUITING

Local Institution - 0086

Murdoch, Western Australia, Australia

Site Status WITHDRAWN

Local Institution - 0076

Brussels, Bruxelles-Capitale, Région de, Belgium

Site Status WITHDRAWN

UZ Leuven

Leuven, Vlaams-Brabant, Belgium

Site Status RECRUITING

UZ Brussel

Brussels, , Belgium

Site Status RECRUITING

Local Institution - 0063

Edegem, , Belgium

Site Status NOT_YET_RECRUITING

Centre Hospitalier Régional de la Citadelle

Liège, , Belgium

Site Status RECRUITING

Local Institution - 0071

Liège, , Belgium

Site Status WITHDRAWN

Local Institution - 0083

Hamilton, Ontario, Canada

Site Status WITHDRAWN

Local Institution - 0104

Toronto, Ontario, Canada

Site Status NOT_YET_RECRUITING

Local Institution - 0082

Toronto, Ontario, Canada

Site Status NOT_YET_RECRUITING

CHU de Toulouse - Hôpital des Enfants

Toulouse, Haute-Garonne, France

Site Status RECRUITING

Hospices Civils de Lyon - Hôpital Femme Mère Enfant

Bron, , France

Site Status RECRUITING

Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre

Caen, , France

Site Status RECRUITING

Hôpital Universitaire Necker Enfants Malades

Paris, , France

Site Status RECRUITING

Local Institution - 0073

Paris, , France

Site Status WITHDRAWN

Klinikum der Ludwig-Maximilians-Universitaet Muenchen

München, Bavaria, Germany

Site Status RECRUITING

Universitätsklinikum Leipzig

Leipzig, Saxony, Germany

Site Status RECRUITING

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, , Germany

Site Status RECRUITING

Schneider Children's Medical Center

Petah Tikva, Central District, Israel

Site Status RECRUITING

Shaare Zedek Medical Center

Jerusalem, Jerusalem, Israel

Site Status RECRUITING

Rambam Health Care Campus

Haifa, Northern District, Israel

Site Status RECRUITING

Aichi Children's Health and Medical Center

Ōbu, Aichi-ken, Japan

Site Status RECRUITING

Kurume University Hospital

Kurume-shi, Fukuoka, Japan

Site Status RECRUITING

Komatsu Municipal Hospital

Komatsu, Ishikawa-ken, Japan

Site Status RECRUITING

Saiseikai Yokohamashi Tobu Hospital

Yokohama, Kanagawa, Japan

Site Status RECRUITING

Osaka Medical and Pharmaceutical University Hospital

Takatsuki, Osaka, Japan

Site Status RECRUITING

Institute of Science Tokyo Hospital

Bunkyo-Ku, Tokyo, Japan

Site Status RECRUITING

National Center for Child Health and Development

Setagaya-ku, Tokyo, Japan

Site Status RECRUITING

Tokyo Medical University Hospital

Shinjuku-ku, Tokyo, Japan

Site Status RECRUITING

Hiroshima University Hospital

Hiroshima, , Japan

Site Status RECRUITING

Juntendo University Hospital

Tokyo, , Japan

Site Status RECRUITING

Local Institution - 0084

Krakow, Lesser Poland Voivodeship, Poland

Site Status WITHDRAWN

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status RECRUITING

WIP Warsaw IBD Point Profesor Kierkuś

Warsaw, Masovian Voivodeship, Poland

Site Status RECRUITING

Centrum Zdrowia Dziecka w Warszawie

Warsaw, Masovian Voivodeship, Poland

Site Status RECRUITING

Local Institution - 0015

Rzeszów, Podkarpackie Voivodeship, Poland

Site Status WITHDRAWN

Local Institution - 0013

Gdansk, Pomeranian Voivodeship, Poland

Site Status WITHDRAWN

Local Institution - 0079

Gdansk, Pomeranian Voivodeship, Poland

Site Status WITHDRAWN

Twoja Przychodnia SCM

Szczecin, West Pomeranian Voivodeship, Poland

Site Status RECRUITING

Local Institution - 0092

Lodz, Łódź Voivodeship, Poland

Site Status WITHDRAWN

Local Institution - 0098

San Juan, , Puerto Rico

Site Status NOT_YET_RECRUITING

Local Institution

Moscow, , Russia

Site Status WITHDRAWN

Local Institution

Moskva, , Russia

Site Status WITHDRAWN

Local Institution - 0048

Badalona, Barcelona [Barcelona], Spain

Site Status COMPLETED

Local Institution - 0051

Esplugues de Llobregat, Barcelona [Barcelona], Spain

Site Status COMPLETED

Local Institution - 0044

Madrid, Madrid, Comunidad de, Spain

Site Status COMPLETED

Local Institution - 0057

Madrid, , Spain

Site Status COMPLETED

Local Institution - 0050

Madrid, , Spain

Site Status WITHDRAWN

Birmingham Children's Hospital

Birmingham, England, United Kingdom

Site Status RECRUITING

King's College Hospital

London, Greater London, United Kingdom

Site Status RECRUITING

Barts Health NHS Trust

London, London, City of, United Kingdom

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States Australia Belgium Canada France Germany Israel Japan Poland Puerto Rico Russia Spain United Kingdom

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

BMS Study Connect Contact Center www.BMSStudyConnect.com

Role: CONTACT

855-907-3286

First line of the email MUST contain the NCT# and Site #.

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Kalyan Ray Parashette, Site 0087

Role: primary

505-274-0704

Shervin Rabizadeh, Site 0074

Role: primary

310-423-7100

Jonathan Moses, Site 0080

Role: primary

650-721-2250

Site 0096

Role: primary

Site 0101

Role: primary

Site 0100

Role: primary

Dawn Ebach, Site 0049

Role: primary

319-471-1301

Noah Hoffman, Site 0090

Role: primary

207-662-5522

Athos Bousvaros, Site 0005

Role: primary

617-699-1021

Basavaraj Kerur, Site 0095

Role: primary

774-441-8082

Kristen Cares, Site 0093

Role: primary

586-909-8958

Michael Stephens, Site 0070

Role: primary

111111

Charles Samson, Site 0053

Role: primary

513-518-8949

JOSEPH PICORARO, Site 0040

Role: primary

212-305-5903

Jessica Barry, Site 0036

Role: primary

216444231

Stefany Garrity, Site 0045

Role: primary

508-523-1571

Site 0099

Role: primary

Site 0103

Role: primary

Lina Karam, Site 0067

Role: primary

832-822-3612

Ghassan Wahbeh, Site 0060

Role: primary

111111

Raghu Varier, Site 0046

Role: primary

503-847-4748

Abdul Elkadri, Site 0037

Role: primary

414-266-3282

Shoma Dutt, Site 0094

Role: primary

0298453999

Edward Giles, Site 0085

Role: primary

+61395943577

Ilse Hoffman, Site 0059

Role: primary

003216343343

Elisabeth De Greef, Site 0056

Role: primary

003224749399

Site 0063

Role: primary

Emeline Bequet, Site 0061

Role: primary

32 4321 54 67

Site 0104

Role: primary

Site 0082

Role: primary

EMMANUEL MAS, Site 0058

Role: primary

0685946782

Remi Duclaux-Loras, Site 0022

Role: primary

0472357050

Claire Dupont-Lucas, Site 0030

Role: primary

33668354806

Frank Ruemmele, Site 0017

Role: primary

0615781674

Tobias Schwerd, Site 0032

Role: primary

004989440057727

Gunter Flemming, Site 0097

Role: primary

+49-341-9726111

Martin Laass, Site 0031

Role: primary

00493514583449

Dror Shouval, Site 0020

Role: primary

03-9253673

Dan Turner, Site 0019

Role: primary

02-6666482

Ron Shaoul, Site 0018

Role: primary

04-7774381

Naomi Iwata, Site 0025

Role: primary

81562430500

Tatsuki Mizuochi, Site 0011

Role: primary

+81-942-35-3311

HISASHI KANEDA, Site 0068

Role: primary

81-761-22-7111

shuichiro umetsu, Site 0038

Role: primary

+81455763000

Emiri Kaji, Site 0021

Role: primary

81-726-83-1221

Toshimitsu Fujii, Site 0024

Role: primary

+81-3-5803-5877

Katsuhiro Arai, Site 0009

Role: primary

+81-3-3416-0181

Norito Tsutsumi, Site 0033

Role: primary

0333426111

Shiro Oka, Site 0069

Role: primary

Takahiro Kudo, Site 0010

Role: primary

+81-3-3813-3111

Tomasz Pytrus, Site 0012

Role: primary

+48 71 7703045

Monika Meglicka, Site 0043

Role: primary

+48603508908

Jaroslaw Kierkus, Site 0014

Role: primary

+48500111648

Beata Gawdis-Wojnarska, Site 0088

Role: primary

+48664929399

Site 0098

Role: primary

Rafeeq Muhammed, Site 0054

Role: primary

07788861236

Babu Vadamalayan, Site 0026

Role: primary

02032991674

Protima Deb, Site 0066

Role: primary

02035942473

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

IM047-001

Identifier Type: -

Identifier Source: org_study_id

2023-509248-86

Identifier Type: OTHER

Identifier Source: secondary_id