An Open-label Study of Ozanimod in Moderate to Severe Ulcerative Colitis in Clinical Practice

NCT ID: NCT05369832

Last Updated: 2025-05-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

139 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-16

Study Completion Date

2025-04-11

Brief Summary

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The purpose of this study is to explore the safety, efficacy, effects on quality of life (QOL), and biomarker response of ozanimod in participants with moderate to severely active ulcerative colitis (UC) in clinical practice.

Detailed Description

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Conditions

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Colitis, Ulcerative

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cohort 1 - Advanced therapy-naive

Group Type EXPERIMENTAL

Ozanimod

Intervention Type DRUG

Specified dose on specified days

Cohort 2 - Advanced therapy-exposed

Group Type EXPERIMENTAL

Ozanimod

Intervention Type DRUG

Specified dose on specified days

Interventions

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Ozanimod

Specified dose on specified days

Intervention Type DRUG

Other Intervention Names

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Zeposia® RPC-1063 BMS-986374

Eligibility Criteria

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Inclusion Criteria

* A diagnosis of ulcerative colitis (UC), with signs and symptoms consistent with UC for at least 3 months prior to the first study intervention administration
* Moderate to severely active UC disease activity, defined as a modified Mayo score of 4 through 9, inclusive, with the following minimum subscores:

i) An SF subscore ≥ 1, AND ii) An RB subscore ≥ 1, AND iii) An ES ≥ 2 (endoscopy performed within 60 days of the first study intervention administration).
* Report of a previous colonoscopy that documents extent of disease

Exclusion Criteria

* Current or recent (within 3 months of screening) evidence of fulminant colitis, toxic megacolon, or bowel perforation
* Extensive colonic resection or current stoma
* Colonic dysplasia that has not been removed
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution - 0048

Dothan, Alabama, United States

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Local Institution - 0206

Chandler, Arizona, United States

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Local Institution - 0216

Gilbert, Arizona, United States

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Local Institution - 0125

Sun City, Arizona, United States

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Local Institution - 0195

Tucson, Arizona, United States

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Local Institution - 0045

North Little Rock, Arkansas, United States

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Local Institution - 0165

Apple Valley, California, United States

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Local Institution - 0162

Camarillo, California, United States

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Local Institution - 0014

Lancaster, California, United States

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OM Research LLC - Lancaster - ClinEdge - PPDS

Lancaster, California, United States

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Local Institution - 0209

Los Angeles, California, United States

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Local Institution - 0002

San Diego, California, United States

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Local Institution - 0208

San Diego, California, United States

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Local Institution - 0185

San Jose, California, United States

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Local Institution - 0178

Littleton, Colorado, United States

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Gastro Florida

Clearwater, Florida, United States

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Local Institution - 0018

Clearwater, Florida, United States

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Local Institution - 0050

Homestead, Florida, United States

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Local Institution - 0026

Lighthouse PT, Florida, United States

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Local Institution - 0167

Miami, Florida, United States

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Local Institution - 0049

Miami Lakes, Florida, United States

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Wellness Clinical Research-Miami Florida

Miami Lakes, Florida, United States

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Gastroenterology Group of Naples

Naples, Florida, United States

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Local Institution - 0003

Naples, Florida, United States

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Local Institution - 0058

Orange Park, Florida, United States

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Local Institution - 0205

Orlando, Florida, United States

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Local Institution - 0037

Palm Harbor, Florida, United States

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Local Institution - 0179

Wellington, Florida, United States

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Local Institution - 0027

Roswell, Georgia, United States

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Local Institution - 0198

Arlington Heights, Illinois, United States

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Local Institution - 0051

Chicago, Illinois, United States

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Local Institution - 0098

Gurnee, Illinois, United States

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Local Institution - 0192

Kansas City, Kansas, United States

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Local Institution - 0181

Topeka, Kansas, United States

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Local Institution - 0183

Louisville, Kentucky, United States

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Local Institution - 0200

Baton Rouge, Louisiana, United States

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Local Institution - 0171

Chevy Chase, Maryland, United States

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Local Institution - 0191

Glen Burnie, Maryland, United States

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Local Institution - 0199

Boston, Massachusetts, United States

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Local Institution - 0196

Worcester, Massachusetts, United States

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Local Institution - 0174

Plymouth, Minnesota, United States

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Local Institution - 0184

Ocean Springs, Mississippi, United States

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Local Institution - 0024

Chesterfield, Missouri, United States

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Local Institution - 0213

Weldon Spring, Missouri, United States

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Local Institution - 0180

Englewood, New Jersey, United States

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Local Institution - 0084

Brooklyn, New York, United States

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Local Institution - 0187

New York, New York, United States

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Local Institution - 0059

New York, New York, United States

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NYU Langone Health -Inflammatory Bowel Disease Center

New York, New York, United States

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Local Institution - 0176

New York, New York, United States

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Local Institution - 0170

Utica, New York, United States

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Carolina Digestive Diseases

Greenville, North Carolina, United States

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Local Institution - 0005

Cincinnati, Ohio, United States

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University of Cincinnati Physicians Company

Cincinnati, Ohio, United States

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Local Institution - 0188

Columbus, Ohio, United States

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Local Institution - 0061

Mentor, Ohio, United States

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Local Institution - 0060

Providence, Rhode Island, United States

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Local Institution - 0177

Cordova, Tennessee, United States

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Local Institution - 0168

Nashville, Tennessee, United States

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Local Institution - 0038

Bellaire, Texas, United States

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Novel Research LLC

Bellaire, Texas, United States

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Local Institution - 0138

Dallas, Texas, United States

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Local Institution - 0036

Houston, Texas, United States

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Local Institution - 0163

Houston, Texas, United States

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Ace Clinical Research Group: Digestive Health Associates

Houston, Texas, United States

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Houston Methodist Hospital

Houston, Texas, United States

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Local Institution - 0052

Houston, Texas, United States

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Local Institution - 0129

Katy, Texas, United States

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Local Institution - 0161

Lubbock, Texas, United States

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GI Alliance: Mansfield - TDDC

Mansfield, Texas, United States

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Local Institution - 0039

Mansfield, Texas, United States

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Local Institution - 0201

San Antonio, Texas, United States

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Local Institution - 0043

San Antonio, Texas, United States

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San Antonio Gastroenterology

San Antonio, Texas, United States

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Local Institution - 0166

San Marcos, Texas, United States

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Local Institution - 0046

Tyler, Texas, United States

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Tyler Research Institute, LLC

Tyler, Texas, United States

Site Status

Local Institution - 0091

Webster, Texas, United States

Site Status

Local Institution - 0193

Ogden, Utah, United States

Site Status

Local Institution - 0169

Salt Lake City, Utah, United States

Site Status

Local Institution - 0197

Lynchburg, Virginia, United States

Site Status

Local Institution - 0130

Seattle, Washington, United States

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Local Institution - 0189

Tacoma, Washington, United States

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Local Institution - 0017

Madison, Wisconsin, United States

Site Status

University of Wisconsin Hospital and Clinics

Madison, Wisconsin, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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IM047-029

Identifier Type: -

Identifier Source: org_study_id

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