Argyle Safety Fistula Cannula With Anti-reflux Valve Clinical Study

NCT ID: NCT05927532

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-10

Study Completion Date

2024-12-15

Brief Summary

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The purpose of the investigation is to confirm the safety and performance of the Argyle™ Safety Fistula Cannula with Anti-reflux Valve for hemodialysis treatment.

Detailed Description

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The study will be performed at up to 5 US hemodialysis clinics.

Qualified patients who choose to participate and sign informed consent will be enrolled in the study. The investigational sites chosen to participate in this study will be trained on the insertion procedure using plastic fistula cannulas according to established curriculum. A combination of didactic training followed by insertion using a cannulation arm will be conducted. Cannulation on consented subjects will begin after the inserter demonstrates proficiency on the cannulation arm. Proficiency definitions are outlined in the protocol. After two supervised (by Medtronic and/or dedicated, trained super user) successful cannulations on consented subjects, the clinician will be permitted to cannulate without supervision.

Data supporting the primary, secondary, and exploratory objectives will be captured following thirty-six (36) hemodialysis sessions for each enrolled subject.

Cannulations will be performed by a minimum of five different clinicians at up to 5 dialysis clinic sites.

The investigational sites chosen to participate in this study will be trained on the insertion procedure using plastic fistula cannulas for a pre-determined period and according to established curriculum. A combination of didactic training followed by insertion using a cannulation arm will be conducted. After two supervised (by Medtronic and/or dedicated, trained super user) successful cannulations on consented subjects, the clinician will be permitted to cannulate without supervision and the data collection for the primary and secondary objectives will begin. Hemodialysis sessions will be performed, according to the investigator's prescription, throughout the duration of the study. Dialysis adequacy will be verified at baseline and during the mid-week session on weeks 1, 3, 6 and 12. Other than the blood sampling, there are no study-specific procedures, other than cannulation with the Argyle™ Safety Fistula Cannula with Anti-Reflux Valve, that will be required.

Conditions

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End Stage Renal Failure on Dialysis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Argyle Fistula Cannula Subjects

All subjects enrolled in the study and treated with the Argyle Safety Fistula Cannula with Anti-reflux Valve

Group Type EXPERIMENTAL

Argyle Safety Fistula Cannula with Anti-Reflux Valve

Intervention Type DEVICE

The Argyle Safety Fistula Cannula with Anti-reflux Valve will be used 3x a week for 12 weeks in subjects with an arteriovenous fistulae (AVF) fistula

Interventions

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Argyle Safety Fistula Cannula with Anti-Reflux Valve

The Argyle Safety Fistula Cannula with Anti-reflux Valve will be used 3x a week for 12 weeks in subjects with an arteriovenous fistulae (AVF) fistula

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject who is aged 18 years or older who signed informed consent
* Subject is undergoing in-center hemodialysis
* Subject has an arteriovenous fistulae (AVF) fistula that was determined to be mature by standard clinical definition

Exclusion Criteria

* Subject is enrolled in another study that could confound the results of this study, without documented pre-approval
* Subject with an existing arteriovenous graft
* Subjects with known allergies to plastics
* Subjects who are unable to read or respond to the questionnaire about satisfaction
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic - MITG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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DaVita Hartford

Hartford, Connecticut, United States

Site Status

DaVita Columbus

Columbus, Georgia, United States

Site Status

DaVita Norfolk

Norfolk, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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MDT19046

Identifier Type: -

Identifier Source: org_study_id