Facial Emotion Recognition in Patients With Euthymic Bipolar Disorder I and II

NCT ID: NCT05922956

Last Updated: 2025-11-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-04-01
• Study Completion Date: 2023-07-01

Brief Summary

The facial emotion recognition is a basic social skill for successful social interactions. Several meta-analyses and recent studies found impairments of the perception of facial emotions in patients with euthymic bipolar disorder. Few studies compared recognition of facial emotions impairments during euthymia in patients with bipolar disorder type 1 and 2. These studies included low population samples (N<60). There were discrepancies in results of these studies. Szanto suggested that facial emotion recognition impairments were correlated with suicidal risk and social isolation. These impairments should be taking into account regarding psycho-social treatments in patients with bipolar disorder.

This study aims to evaluate facial emotion recognition in patients with bipolar I and II disorders compared to healthy controls, using the facial emotion recognition test (TREF). The objective of the present study is to compare TREF scores in a group of patients with bipolar 1, a group of patients with bipolar 2 disorder and a group with healthy controls. In addition, the investigators will investigate the relationships between TREF scores and levels of self-esteem and mental well-being.

Conditions

Social Cognition; Facial Emotion Recognition; Facial Affect; Bipolar Disorder I and II

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

patients with bipolar disorder 1

Group Type: EXPERIMENTAL

Facial emotion recognition test

Intervention Type: OTHER

Facial emotion recognition test (TREF), questionnaires including self-administered questionnaires

patients with bipolar disorder 2

Group Type: EXPERIMENTAL

Facial emotion recognition test

Intervention Type: OTHER

Facial emotion recognition test (TREF), questionnaires including self-administered questionnaires

healthy controls

Group Type: ACTIVE_COMPARATOR

Facial emotion recognition test

Intervention Type: OTHER

Facial emotion recognition test (TREF), questionnaires including self-administered questionnaires

Interventions

Facial emotion recognition test

Facial emotion recognition test (TREF), questionnaires including self-administered questionnaires

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient group :
• Male or female patients, between 18 and 60 years old
• Diagnosis of Bipolar Disorder I or Bipolar Disorder II according to DSM-IV criteria, using the French version of the Mini-International Neuropsychiatric Interview (MINI)
• Strictly euthymic defined by Hamilton Depression Rating Scale (17 items) ≤ 5 and Young Mania Rating Scale ≤ 5 for at least two months.
• Native French speakers
• Affiliated to the French social security system
• Giving their written informed consent

Control group :

• Male or female control subjects, aged between 18 and 60 years old, assessed using TREF
• Native French speakers
• Giving their written informed consent

Exclusion Criteria

• Patient group :
• History of mental retardation assessed by the French version of the National Adult Reading Test
• Neurological illness or any clinical condition that could affect cognitive performance (history of head injury with loss of consciousness lasting more than 5 minutes multiple sclerosis, stroke etc.)
• Electroconvulsive therapy within the last 6 months
• Alcohol and Drug dependence (except tobacco and caffeine) according to DSM-IV criteria using the French version of the Mini-International Neuropsychiatric Interview (MINI).
• Learning disability or difficulty with fluent use of the French language
• Patient with mandatory care
• Long-Term use of non-psychotropic medication with psychotropic effects (opiates, Baclofen)

Control group :

• History of mental retardation estimated by the French version of the National Adult Reading Test
• Neurological illness or any clinical condition that could affect cognitive performance (history of head injury with loss of consciousness lasting more than 5 minutes multiple sclerosis, stroke etc.)
• Current Mood disorder/ Lifetime Psychotic Disorder according to DSM-IV criteria using the French version of the Mini-International Neuropsychiatric Interview (MINI)
• Neither history of psychotic or affective disorders in a first-degree family member
• Alcohol and Drug dependence (except tobacco and caffeine) according to DSM-IV criteria using the French version of the Mini-International Neuropsychiatric Interview (MINI)
• Learning disability or difficulty with fluent use of the French language
• Long-Term use of non-psychotropic drugs with psychotropic effects (opiates, Baclofen) and psychotropic drugs

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier le Vinatier

UNKNOWN

Sponsor Role: collaborator

Pôle Ressource Évaluation et Réhabilitation Psycho-sociale, EPSM de l'Oise

UNKNOWN

Sponsor Role: collaborator

Centre de santé mentale MGEN

UNKNOWN

Sponsor Role: collaborator

Centre Hospitalier Philippe Pinel, Amiens

UNKNOWN

Sponsor Role: collaborator

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHU Amiens

Amiens, , France

Countries

France

Other Identifiers

PI2020_843_0009

Identifier Type: -

Identifier Source: org_study_id