Reward and Punishment Sensitivity in Bipolar Disorders

NCT ID: NCT04237610

Last Updated: 2020-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-24

Study Completion Date

2022-02-23

Brief Summary

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Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical settings. Whereas distinguishing BD-I and BD-II main subtypes has a significant relevance for treatment strategy and for outcome, there are currently no clinical determinants of the BD subtype which could be used as early diagnostic predictors.

* While neurobiological specificity of each BD subtype is still controversial, available evidence suggest different dopaminergic abnormalities in each subtype. Dopaminergic function is involved in decision making and reward processing which may represent useful BD subtype markers.
* This study aims at assessing decision making during appetitive and punitive reinforcement learning in patients with BD I and BD II subtypes compared to healthy controls

Detailed Description

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Conditions

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Bipolar Disorder

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Bipolar disorder type I

behavioral assessment

Intervention Type BEHAVIORAL

Probabilistic learning task

Bipolar disorder type II

behavioral assessment

Intervention Type BEHAVIORAL

Probabilistic learning task

healthy controls

behavioral assessment

Intervention Type BEHAVIORAL

Probabilistic learning task

Interventions

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behavioral assessment

Probabilistic learning task

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* bipolar disorder (BD) type I or II, according to DSM (Diagnostic and Statistical Manual)-5 criteria
* Montgomery and Asberg Depression Rating Scale (MADRS) score \< 15
* Young Mania Rating Scale (YMRS) score \< 12

Exclusion Criteria

* other main diagnosis than bipolar disorder
* other medical condition leading to cognitive deterioration
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu Grenoble Alpes

Grenoble, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Mircea POLOSAN, MD, PhD

Role: CONTACT

0033476765414

Arnaud POUCHON, MD

Role: CONTACT

Facility Contacts

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Polosan Mircea

Role: primary

0033476765414

Other Identifiers

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2018-A01962-53

Identifier Type: OTHER

Identifier Source: secondary_id

38RC18.171

Identifier Type: -

Identifier Source: org_study_id

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