Endophenotype Characterization of a Family Psychiatric Disorder
NCT ID: NCT02843997
Last Updated: 2016-07-26
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
UNKNOWN
Clinical Phase
NA
Total Enrollment
29 participants
Study Classification
INTERVENTIONAL
Study Start Date
2015-02-28
Study Completion Date
2018-02-28
Brief Summary
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Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.
The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.
The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.
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Detailed Description
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Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.
The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.
The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.
Conditions
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Healthy Volunteer
Study Design
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Allocation Method
NA
Intervention Model
SINGLE_GROUP
Blinding Strategy
NONE
Study Groups
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Healthy volunteers
Members of a family
Group Type
OTHER
Endophenotype and sequencing
Intervention Type
GENETIC
Draw an endophenotype and genetic study
Interventions
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Endophenotype and sequencing
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Intervention Type
GENETIC
Eligibility Criteria
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Inclusion Criteria
* Members of a family adult (more than 18 years)
* Signed informed consents
* Registered to a French social security or possesor of the European Health Insurance Card
* Signed informed consents
* Registered to a French social security or possesor of the European Health Insurance Card
Exclusion Criteria
Clinical part :
* Refusal to sign the participation study consent.
* Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.
Genetic part :
* Refusal to sign the genetic sample consent.
* Refusal to sign the participation study consent.
* Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.
Genetic part :
* Refusal to sign the genetic sample consent.
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
Yes
Sponsors
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University Hospital, Grenoble
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Jérôme Holtzmann, Doctor
Role: PRINCIPAL_INVESTIGATOR
Grenoble Hospital University
Locations
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UniversityHospitalGrenoble
La Tronche, , France
Site Status
RECRUITING
Countries
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France
Central Contacts
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Facility Contacts
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References
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Other Identifiers
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38RC14.321
Identifier Type: -
Identifier Source: org_study_id
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