Effects of StellaLife Oral Care Recovery Kit on Palatal Wound Healing After Free Gingival Graft

NCT ID: NCT05921513

Last Updated: 2023-06-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-15

Study Completion Date

2024-07-30

Brief Summary

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This study looks to compare the clinical effects of StellaLife VEGA Oral Care Kit with chlorhexidine mouth-rinse on patient comfort, wound healing, wound epithelialization, bacterial levels, and colonization of the wounds.

Detailed Description

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A total of 60 participants will be recruited from those needing and have been treatment planned for a free gingival graft surgery to increase keratinized gum. The study subjects will be randomly allocated to either negative control group (NC), chlorhexidine group (C) or StellaLife group (S) by randomization done using a computer-generated table.

The NC group is provided normal saline mouth-rinse to rinse 2 times per day along with placebo gel to be applied 2 times and placebo oral spray. The S group will use StellaLife Oral Care mouth-rinse, gel and spray 2 times per day. The C group will use chlorhexidine mouth-rinse and placebo gel and spray 2 times per day. All groups beginning the same day and continuing for the duration of two weeks. All patients will receive a protective splint. Following this, subjective and objective measurements on the success of the mouthwash and oral care kit will be measured.

Patients will be evaluated post operatively following surgery as mentioned below:

* Wound Healing Assessment and Epithelization Assessment: Postoperative Days 1, 5, 14, 21 and 28
* Oral Health Impact Profile-14 and Functional Pain Scale: Starting on the day of the surgery and Postoperative Days 1, 5, 14, 21 and 28
* Wound Exudate assessment: Samples collected on Postoperative Days 1, 5, 14, 21 and 28
* Wound Plaque assessment: Starting on the day of the surgery and Postoperative Days 1, 5, 14, 21 and 28

Conditions

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Wound Heal

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel model: Patient will receive either normal saline mouth-rinse to rinse, or Chlorhexidine mouth-rinse with placebo gel and placebo oral spray or Stellalife Oral Care Kit with mouthrinse, gel and oral spray.
Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants
The participants will be masked to which mouth-rinse, gel and spray they are receiving.

Study Groups

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NC Group

This group is provided normal saline mouth-rinse to rinse 2 times per day along with placebo gel to be applied 2 times and placebo oral spray.

Group Type PLACEBO_COMPARATOR

Free Gingival Graft Procedure

Intervention Type PROCEDURE

This procedure is done to increase the width of keratinized gingiva around teeth or dental implant. The healing of the palatal wound at the donor site will be recorded.

S Group

This group is provided StellaLife Oral Care kit's mouth-rinse, gel and spray 2 times per day.

Group Type EXPERIMENTAL

Free Gingival Graft Procedure

Intervention Type PROCEDURE

This procedure is done to increase the width of keratinized gingiva around teeth or dental implant. The healing of the palatal wound at the donor site will be recorded.

C Group

This group is provided chlorhexidine mouth-rinse and placebo gel and spray 2 times per day.

Group Type ACTIVE_COMPARATOR

Free Gingival Graft Procedure

Intervention Type PROCEDURE

This procedure is done to increase the width of keratinized gingiva around teeth or dental implant. The healing of the palatal wound at the donor site will be recorded.

Interventions

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Free Gingival Graft Procedure

This procedure is done to increase the width of keratinized gingiva around teeth or dental implant. The healing of the palatal wound at the donor site will be recorded.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults aged ≥18 years,
* No history of medication affecting periodontal status in the last 6 months,
* No history of allergy to study medication or material,
* No use of tobacco,
* No history of pregnancy or lactation or contraceptive medication
* Good oral hygiene.

Exclusion Criteria

* Previous palatal surgery
* Patient on anticoagulant therapy
* Uncontrolled diabetes,
* Rheumatoid arthritis,
* Osteoporosis.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Louisiana State University Health Sciences Center in New Orleans

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Vinayak Joshi

Role: PRINCIPAL_INVESTIGATOR

LSUHSC, School of Dentistry, New Orleans, LA

Locations

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LSUHSC School of Dentistry

New Orleans, Louisiana, United States

Site Status

Countries

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United States

Central Contacts

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Vinayak Joshi, MS

Role: CONTACT

504-941-8280

Amber Kreko, DDS

Role: CONTACT

Facility Contacts

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Vinayak Joshi, MS, PhD

Role: primary

Role: backup

Other Identifiers

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4863

Identifier Type: -

Identifier Source: org_study_id

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